Predictors of silent corticotroph adenoma recurrence; a large retrospective single center study and systematic literature review
| العنوان: | Predictors of silent corticotroph adenoma recurrence; a large retrospective single center study and systematic literature review |
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| المؤلفون: | Aclan Dogan, Maria Fleseriu, Chris G. Yedinak, Justin S. Cetas, Fabienne Langlois, Shirley McCartney, Dawn Shao Ting Lim, Isabelle Cetas |
| المصدر: | Pituitary. 21:32-40 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adenoma, Adult, Male, Reoperation, medicine.medical_specialty, Pathology, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Adrenocorticotropic hormone, Steroidogenic Factor 1, Single Center, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Adrenocorticotropic Hormone, Risk Factors, Pituitary adenoma, Internal medicine, Biomarkers, Tumor, medicine, Humans, Hypophysectomy, Retrospective Studies, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Cushing's disease, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Radiation therapy, ACTH-Secreting Pituitary Adenoma, Treatment Outcome, Chemotherapy, Adjuvant, Cohort, Cavernous sinus, Female, Radiotherapy, Adjuvant, Neoplasm Recurrence, Local, business, 030217 neurology & neurosurgery |
| الوصف: | Silent corticotroph adenomas (SCAs) are clinically silent and non-secreting, but exhibit positive adrenocorticotropic hormone (ACTH) immunostaining. We characterized a single center cohort of SCA patients, compared the SCAs to silent gonadotroph adenomas (SGAs), identified predictors of recurrence, and reviewed and compared the cohort to previously published SCAs cases. Retrospective review of SCA and SGA surgically resected patients over 10 years and 6 years, respectively. Definitions; SCA—no clinical or biochemical evidence of Cushing’s syndrome and ACTH positive immunostaining, and SGA—steroidogenic factor (SF-1) positive immunostaining. A systematic literature search was undertaken using Pubmed and Scopus. Review revealed 814 pituitary surgeries, 39 (4.8%) were SCAs. Mean follow-up was 6.4 years (range 0.5–23.8 years). Pre-operative magnetic resonance imaging demonstrated sphenoid and/or cavernous sinus invasion in 44%, 33% were > 50% cystic, and 28% had high ACTH levels pre-operatively. Compared to SGAs (n = 70), SCAs were of similar size and invasiveness (2.5 vs. 2.9 cm, p = 0.2; 44 vs. 41%, p = 0.8, respectively), but recurrence rate was higher (36 vs. 10%, p = 0.001) and more patients received radiation therapy (18 vs. 3%, p = 0.006). Less cystic tumors (0 vs. 50%, p |
| تدمد: | 1573-7403 1386-341X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9bc25e03a03c7af4023ee448f99d69Test https://doi.org/10.1007/s11102-017-0844-4Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ed9bc25e03a03c7af4023ee448f99d69 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737403 1386341X |
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