A specific mode of microsatellite instability is a crucial biomarker in adult T-cell leukaemia/lymphoma patients
| العنوان: | A specific mode of microsatellite instability is a crucial biomarker in adult T-cell leukaemia/lymphoma patients |
|---|---|
| المؤلفون: | Kei Fujii, Mototsugu Shimokawa, Kenichi Taguchi, Yasunobu Abe, Kaname Miyashita, Jun Okamura, Mitsuaki A. Yoshida, Shinya Oda, Naokuni Uike |
| المصدر: | Journal of Cancer Research and Clinical Oncology |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Pathology, DNA mismatch repair, medicine.medical_treatment, Kaplan-Meier Estimate, Drug resistance, Biology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biomarkers, Tumor, medicine, Chemotherapy, Humans, Leukemia-Lymphoma, Adult T-Cell, Aged, Aged, 80 and over, Hematology, Gene Expression Regulation, Leukemic, Microsatellite instability, Biomarker, General Medicine, Middle Aged, Prognosis, medicine.disease, digestive system diseases, Lymphoma, Adult T-cell leukaemia/lymphoma, MutS Homolog 2 Protein, Treatment Outcome, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, Biomarker (medicine), Microsatellite, Female, Original Article – Cancer Research, MutL Protein Homolog 1 |
| الوصف: | Purpose Microsatellite instability (MSI) has been a long-standing biomarker candidate for drug resistance in tumour cells. Despite numerous clinical studies, the data in the literature are not conclusive. The complexity of the MSI phenomenon in some malignancies may, at least partly, account for the discrepancy. In addition, methodological problems are also pointed out in the assay techniques. We previously established a unique fluorescent technique in which the major methodological problems in conventional assays are overcome. Application of this technique has revealed two distinct modes of microsatellite alterations, i.e. Type A and Type B. More importantly, we demonstrated that Type A MSI is the direct consequence of defective DNA mismatch repair (MMR) that causes cellular resistance against antineoplastic agents. Method We first applied this technique to adult T-cell leukaemia/lymphoma (ATLL). Results The MSI phenomenon was indeed observed in ATLLs (4/20, 20%). Intriguingly, the observed microsatellite alterations were invariably Type A, which implies that the tumours were MMR-defective. Indeed, clinical outcomes of patients with these MSI+ tumours were significantly worse. Furthermore, multivariate analysis revealed that Type A MSI is an independent prognostic factor. Conclusion These observations strongly suggest the possibility of Type A MSI as a prognostic and potentially predictive biomarker in ATLL. |
| تدمد: | 1432-1335 0171-5216 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed29df4f92851ced6baf94966e1153e5Test https://doi.org/10.1007/s00432-016-2294-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ed29df4f92851ced6baf94966e1153e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321335 01715216 |
|---|