Assessment of Concordance between 22C3 and SP142 Immunohistochemistry Assays regarding PD-L1 Expression in Non-Small Cell Lung Cancer
| العنوان: | Assessment of Concordance between 22C3 and SP142 Immunohistochemistry Assays regarding PD-L1 Expression in Non-Small Cell Lung Cancer |
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| المؤلفون: | Chao Li, Xiandong Lin, Cheng Huang, Xiaobing Zheng, Haipeng Xu, Xirong Fan, Weifeng Zhu, Kan Jiang, Gen Lin, Biao Wu, Qian Miao, Dan Hu |
| المصدر: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) |
| بيانات النشر: | Nature Publishing Group UK, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Pathology, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Concordance, lcsh:Medicine, Kaplan-Meier Estimate, Epitope, Article, B7-H1 Antigen, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Immunochemistry, Carcinoma, medicine, Humans, lcsh:Science, Lung cancer, Aged, Retrospective Studies, Multidisciplinary, biology, business.industry, lcsh:R, Smoking, Immunotherapy, Middle Aged, medicine.disease, Immunohistochemistry, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, lcsh:Q, Female, Antibody, business |
| الوصف: | Different anti-PD-1 and anti-PD-L1 antibodies bind different epitopes. However, whether the results from the SP142 and 22C3 immunochemistry (IHC) assays can be interchanged to determine patient eligibility for immunotherapy remains largely unknown. Histologic sections from 135 tumor samples were probed with both 22C3 and SP142 antibodies. The concordance of PD-L1 expression determined by the two assays was assessed. Additionally, we evaluated the association of PD-L1 expression detected by different assays with clinicopathological features and prognosis. In total, 105 (77.78%) of 135 samples evaluated by the 22C3-IHC platform produced the same results with the SP142-IHC platform (Kappa value: 0.481, p |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece780d9c6886d9c18e3bea4ee38e2edTest http://europepmc.org/articles/PMC5717240Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ece780d9c6886d9c18e3bea4ee38e2ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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