Age-Specific Levels of Diabetes-Related GAD and IA-2 Antibodies in Healthy Children and Adults
| العنوان: | Age-Specific Levels of Diabetes-Related GAD and IA-2 Antibodies in Healthy Children and Adults |
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| المؤلفون: | Olga Kordonouri, Reinhard Hartmann, Thomas Danne, Anette Grüters-Kieslich, Mikael Knip |
| المصدر: | Journal of Pediatric Endocrinology and Metabolism. 15 |
| بيانات النشر: | Walter de Gruyter GmbH, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Glutamate decarboxylase, Population, Antibodies, Cohort Studies, Endocrinology, Antibody Specificity, Internal medicine, Diabetes mellitus, medicine, Humans, Receptor-Like Protein Tyrosine Phosphatases, Class 8, Child, education, Aged, Aged, 80 and over, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Type 1 diabetes, education.field_of_study, biology, Glutamate Decarboxylase, business.industry, Age Factors, Radioimmunoassay, Middle Aged, medicine.disease, Age specific, Diabetes Mellitus, Type 1, ROC Curve, Child, Preschool, Reference values, Pediatrics, Perinatology and Child Health, biology.protein, Female, Protein Tyrosine Phosphatases, Antibody, business |
| الوصف: | Glutamic acid decarboxylase (GAD) and tyrosine phosphatase IA-2 antibody levels were measured in 375 healthy children and adults and in 187 children with newly diagnosed type 1 diabetes mellitus (DM). GAD antibody levels were determined by radioimmunoassay, and IA-2 antibody levels by immunoprecipitation. Healthy children had higher GAD antibody levels than adults (p < 0.001). The 98th percentile was 1.60 U/ml in children and 1.16 U/ml in adults. IA-2 antibody levels did not differ between these two cohorts. Children with DM had higher GAD and IA-2 antibody levels than healthy children (p |
| تدمد: | 2191-0251 0334-018X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5d357b445e3ce17506cb778ffa9e6fTest https://doi.org/10.1515/jpem.2002.15.1.47Test |
| رقم الانضمام: | edsair.doi.dedup.....ec5d357b445e3ce17506cb778ffa9e6f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21910251 0334018X |
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