Multiple endokrine Neoplasie
| العنوان: | Multiple endokrine Neoplasie |
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| المؤلفون: | Ludwig Schaaf, Friedhelm Raue |
| المصدر: | DMW - Deutsche Medizinische Wochenschrift. 142:1379-1389 |
| بيانات النشر: | Georg Thieme Verlag KG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | endocrine system, Pathology, medicine.medical_specialty, Tumor suppressor gene, endocrine system diseases, medicine.medical_treatment, 030209 endocrinology & metabolism, Neuroendocrine tumors, RET proto-oncogene, Thyroid carcinoma, Pheochromocytoma, 03 medical and health sciences, 0302 clinical medicine, Pancreatic tumor, Proto-Oncogene Proteins, medicine, Humans, MEN1, Multiple endocrine neoplasia, Early Detection of Cancer, business.industry, Multiple Endocrine Neoplasia, Pituitary tumors, Thyroidectomy, General Medicine, medicine.disease, 030220 oncology & carcinogenesis, Mutation, Cancer research, business, Primary hyperparathyroidism |
| الوصف: | Multiple endocrine neoplasia type 1 and 2 are hereditary cancer syndromes. They are characterized by the occurrence of many benign and malignant tumor types, in MEN1 parathyroid tumors, pituitary tumors, and pancreas tumors, in MEN2 medullary thyroid carcinoma, pheochromocytoma, and parathyroid tumors. The autosomal dominant inherited tumor syndromes are caused by mutations in the MEN1 gene, a tumor suppressor gene, and mutations in the RET gene, an activated oncogene, in MEN2. The clinical expression of the different tumors can vary within and between families, with a good genotype-phenotype correlation in MEN2. Early diagnosis and therapy is possible by using biochemical and imaging screening in the families. Early thyroidectomy in young patients with MEN2 results in a high cure rate of MTC. |
| تدمد: | 1439-4413 0012-0472 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb611140d0a420597070a3dfa983cdbTest https://doi.org/10.1055/s-0043-109522Test |
| رقم الانضمام: | edsair.doi.dedup.....ebb611140d0a420597070a3dfa983cdb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14394413 00120472 |
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