Effects of antidiabetic agents on steatosis and fibrosis biomarkers in type 2 diabetes: A real‐world data analysis
| العنوان: | Effects of antidiabetic agents on steatosis and fibrosis biomarkers in type 2 diabetes: A real‐world data analysis |
|---|---|
| المؤلفون: | Federico Ravaioli, Maria Letizia Petroni, Santo Colosimo, Anna Simona Sasdelli, Loris Pironi, Giulio Marchesini, Francesca Marchignoli, Lucia Brodosi, Francesca Alessandra Barbanti |
| المساهمون: | Colosimo, Santo, Ravaioli, Federico, Petroni, Maria L, Brodosi, Lucia, Marchignoli, Francesca, Barbanti, Francesca A, Sasdelli, Anna S, Marchesini, Giulio, Pironi, Loris |
| المصدر: | Liver International |
| بيانات النشر: | John Wiley and Sons Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Data Analysis, endocrine system, medicine.medical_specialty, Glucagon like peptide-1 receptor agonist, Type 2 diabetes, Dipeptidyl-peptidase-4 inhibitor, Gastroenterology, Sodium-glucose cotransporter-2 inhibitor, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Internal medicine, NAFLD, Nonalcoholic fatty liver disease, glucagon like peptide‐1 receptor agonists, sodium‐glucose cotransporter‐2 inhibitors, Medicine, dipeptidyl‐peptidase‐4 inhibitors, Humans, Hypoglycemic Agents, Metabolic & Toxic Liver Diseases, Sodium-Glucose Transporter 2 Inhibitors, Retrospective Studies, Hepatology, business.industry, Fatty liver, medicine.disease, Fibrosis, Metformin, Fatty Liver, Diabetes Mellitus, Type 2, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Original Article, Steatosis, business, Pioglitazone, Body mass index, surrogate biomarkers, Biomarkers, medicine.drug |
| الوصف: | Background & Aims There is intense research for drugs able to reduce disease progression in nonalcoholic fatty liver disease. We aimed to test the impact of novel antidiabetic drugs (dipeptidyl‐peptidase‐4 inhibitors – DPP‐4Is, glucagon‐like peptide‐1 receptor agonists – GLP‐1RAs, sodium‐glucose cotransporter‐2 inhibitors – SGLT‐2Is) on non‐invasive biomarkers of steatosis (fatty liver index, FLI) and fibrosis (Fibrosis‐4 score, FIB‐4) in patients with type 2 diabetes (T2D). Methods Clinical, anthropometric and biochemical parameters were retrospectively analysed in 637 consecutive T2D patients switched from metformin w/wo sulfonylureas and/or pioglitazone to DPP‐4Is, GLP‐1RAs and SGLT‐2Is in a tertiary care setting. 165 patients maintained on original treatments served as controls. The effects on FLI and FIB‐4 at 6‐ and 12‐month follow‐up were analysed by logistic regression after adjustment for baseline differences, computed by propensity scores, and additional adjustment for changes in glycosylated hemoglobin (HbA1c) and body mass index. Results Body mass index, HbA1c and aminotrasferases significantly decreased following switching to GLP‐1RAs and SGLT2‐Is, compared with both controls and DPP‐4Is, whereas only HbA1c was reduced on DPP‐4Is. FLI and FIB‐4 were reduced on GLP‐1RA and SGLT‐2I; logistic regression analysis confirmed a significant improvement of both biomarkers after adjustment for propensity score. The shift of FIB‐4 values towards the category ruling out advanced fibrosis was maintained after additional adjustment for confounders. These effects were confirmed in a sensitivity analysis on effect size. Conclusions Glucagon‐like peptide‐1 receptor agonists and SGLT‐2Is improve biomarkers of steatosis and fibrosis, in keeping with beneficial effects on liver disease progression, and should be considered the treatment of choice in T2D. |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| تدمد: | 1478-3231 1478-3223 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebafd027e60c7db3707279f773bc4eb7Test http://europepmc.org/articles/PMC8248247Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ebafd027e60c7db3707279f773bc4eb7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14783231 14783223 |
|---|