Vitamin D intoxication in patients with cystic fibrosis: report of a single-center cohort
| العنوان: | Vitamin D intoxication in patients with cystic fibrosis: report of a single-center cohort |
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| المؤلفون: | Laurence Henri, Pierre Bastin, Sophie Gohy, Damien Gruson, Silvia Berardis, Thomas Planté-Bordeneuve |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Vitamin, medicine.medical_specialty, Adolescent, Cystic Fibrosis, Science, Population, Single Center, Cystic fibrosis, Gastroenterology, Article, Pulmonary function testing, Cohort Studies, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Humans, Medication Errors, Medicine, 030212 general & internal medicine, Dosing, Vitamin D, Exocrine pancreatic insufficiency, education, Retrospective Studies, education.field_of_study, Multidisciplinary, business.industry, Endocrine system and metabolic diseases, medicine.disease, 030104 developmental biology, chemistry, Cohort, Female, Drug Overdose, business |
| الوصف: | Vitamin D toxicity is associated with accidental overdoses due to manufacturing or intake errors and its secondary hypercalcemia can result in severe morbidity. Although patients with cystic fibrosis are potentially at increased risk for this intoxication as prescription of vitamin D preparations is a common practice in this population, the frequency of such events is currently unknown. We performed a retrospective analysis of all the files of cystic fibrosis patients followed at the Cliniques universitaires Saint-Luc over a 10-year period, recording 25(OH)- and 1,25(OH)2vitamin D levels as well as demographic data, lung function tests, Pseudomonas aeruginosa infection and results from pharmacological analysis of magistral liposoluble vitamins preparations. A total of 244 patients were included in the study. 13 patients (5%) had serum vitamin D levels corresponding to vitamin D overdose. Patients who had experienced an overdose were more likely to be F508del homozygous or suffer from exocrine pancreatic insufficiency. 2 patients developed significant hypercalcemia necessitating monitoring and hospitalization. Errors in the preparation of magistral liposoluble vitamin pills were identified in several intoxicated patients. Retrospective assessment of the dosing errors with the local pharmacists showed that trituration and dosing errors were their most frequent causes. |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb90d98af5584db200bbb88264696e86Test https://doi.org/10.1038/s41598-021-87099-wTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eb90d98af5584db200bbb88264696e86 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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