Immunological features of a lung cancer patient achieving an objective response with anti‐programmed death‐1 blockade therapy
| العنوان: | Immunological features of a lung cancer patient achieving an objective response with anti‐programmed death‐1 blockade therapy |
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| المؤلفون: | Yukiko Kanetsuna, Mariko Takami, Shigetoshi Yoshida, Takahide Toyoda, Toshiko Kamata, Ichiro Yoshino, Hiroko Yoshizawa, Tetsuo Sato, Seiichi Nobuyama, Shinichiro Motohashi, Yuichiro Takeshita, Fumie Ihara |
| المصدر: | Cancer Science |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Case Report, tumor‐infiltrating lymphocyte, surgery, 03 medical and health sciences, 0302 clinical medicine, Immune system, Internal medicine, medicine, Interferon gamma, Memory B cell, Lung cancer, Tumor microenvironment, business.industry, Tumor-infiltrating lymphocytes, anti‐PD‐1 antibody, Germinal center, General Medicine, Immunotherapy, medicine.disease, lung cancer, 030104 developmental biology, 030220 oncology & carcinogenesis, immunotherapy, business, medicine.drug |
| الوصف: | The role of immune checkpoint inhibitors in metastatic lung cancer has been established in recent years and the pretherapeutic profiles of the tumor microenvironment in responders have been increasingly reported. The role of salvage surgery and the immune profiles of the posttherapeutic specimens in patients achieving an objective response have rarely been studied. We report a case of metastatic lung cancer treated by anti‐programmed death‐1 Ab followed by surgical resection. The immune status of the tumor was assessed, showing germinal center formation, memory B cell infiltration, and a high frequency of interferon gamma ‐secreting T cells. The role of salvage surgery and the immune profiles of posttherapeutic specimens in patients achieving an objective response with immune checkpoint inhibitors have rarely been studied. We report a case of metastatic lung cancer treated by anti‐programmed death‐1 Ab followed by surgical resection. The immune status of the tumor microenvironment was assessed, showing germinal center formation, memory B cell infiltration, and a high frequency of T cells with a T helper 1 phenotype. |
| تدمد: | 1349-7006 1347-9032 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb46d25c690760f3ec7ac0b81cd3468dTest https://doi.org/10.1111/cas.14222Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eb46d25c690760f3ec7ac0b81cd3468d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497006 13479032 |
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