Ameliorative Effect of Dangguibuxue Decoction against Cyclophosphamide-Induced Heart Injury in Mice
| العنوان: | Ameliorative Effect of Dangguibuxue Decoction against Cyclophosphamide-Induced Heart Injury in Mice |
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| المؤلفون: | Xiu-mei Ren, Qing-Sheng You, Wei-Nan Li, Qing Ye, Ming-Ming Gu, Shuo Wang, Kun Liu, Fei Wang, Chun-Hui Ma |
| المصدر: | BioMed Research International BioMed Research International, Vol 2018 (2018) |
| بيانات النشر: | Hindawi, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Blood Platelets, 0301 basic medicine, Heart Injury, Article Subject, Cyclophosphamide, lcsh:Medicine, Pharmacology, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, White blood cell, Leukocytes, medicine, Animals, Humans, Platelet, Aspartate Aminotransferases, Creatine Kinase, Pathological, L-Lactate Dehydrogenase, General Immunology and Microbiology, biology, business.industry, lcsh:R, NF-kappa B, Alanine Transaminase, Heart, General Medicine, 030104 developmental biology, medicine.anatomical_structure, Heart Injuries, biology.protein, Creatine kinase, Dangguibuxue decoction, Signal transduction, business, Drugs, Chinese Herbal, Signal Transduction, medicine.drug, Research Article |
| الوصف: | Dangguibuxue decoction (DBD), a kind of Chinese herbal medicine, has been widely used to treat blood deficiency disease in China. In this experiment, we studied the effects of the Dangguibuxue decoction (DBD) on the myocardial injury induced by cyclophosphamide in mice. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and lactic dehydrogenase (LDH) in serum were detected by commercial kits. Total white blood cell (WBCs), platelets, and cytokines pathological changes of heart tissue were also examined. In addition, the protein levels of the NF-кB pathway were detected to reveal its mechanism. The results showed that DBD significantly decreased the levels of ALT, AST, CK, and LDH and increased WBCs in CTX-induced mice. In addition, DBD significantly alleviated pathological changes of heart tissue. DBD significantly reduced the protein expressions of NF-кB signaling pathway. In summary, DBD can be considered an effective drug to alleviate CTX-induced heart damage in mice. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb33bd15728458429ac3adb78d08bbacTest http://europepmc.org/articles/PMC6236918Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eb33bd15728458429ac3adb78d08bbac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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