Effectiveness of ustekinumab in patients with atopic dermatitis: analysis of real-world evidence
| العنوان: | Effectiveness of ustekinumab in patients with atopic dermatitis: analysis of real-world evidence |
|---|---|
| المؤلفون: | Husein Husein-ElAhmed, Martin Steinhoff |
| المصدر: | Journal of Dermatological Treatment. 33:1838-1843 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.drug_class, Dermatology, Real world evidence, Monoclonal antibody, Interleukin-23, Dermatitis, Atopic, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Psoriasis, Ustekinumab, medicine, Humans, In patient, 030203 arthritis & rheumatology, business.industry, Inflammatory skin disease, Antibodies, Monoclonal, Interleukin, Atopic dermatitis, medicine.disease, Interleukin-12, body regions, Treatment Outcome, Immunology, business, medicine.drug |
| الوصف: | Atopic dermatitis (AD) is a common chronic inflammatory condition. Ustekinumab is a human monoclonal antibody approved for psoriasis, that targets the interleukin (IL)-12 and IL-23, and it may also play a role in AD. Administration of ustekinumab in AD is presented in anecdotal reports with conflicting results. Our aim was to evaluate the precise value of ustekinumab on AD.We systematically reviewed published data involving AD treated with ustekinumab. The main outcome was clinical improvement. We classified this in three categories: 'complete response,' 'partial response,' and 'no response.' A multivariant model was used to assess the effectiveness and the following potential predictive factors: gender, age, duration of AD, asthma, previous use of biologics, previous systemic therapies,levels of IgE and duration of ustekinumab therapy.Data on 23 patients were analyzed. Complete AD remission was reported in 8 patients (34.8%), while the absence of response was observed also in 8 patients (34.8%). Partial response was reported in 7 patients (30.4%). No differences were observed with the predictive factors.The IL-12/23 pathway is likely not an attractive target for AD. Other effective treatments are available and should be prioritized with a good safety profile. WHAT'S ALREADY KNOWN ABOUT THIS TOPIC?Administration of ustekinumab in AD (atopic dermatitis) has been presented in anecdotical reports with conflicting results.WHAT DOES THIS STUDY ADD?This work presents the largest cohort of AD patients treated with ustekinumab in a real-world setting.Ustekinumab resulted in similar rates of complete, partial, and negative responses.Our findings demonstrate the IL-12/23 pathway is not an attractive target in AD.More novel and effective treatments for AD are available and should be prioritized.The impact of anti-IL-12/IL-23p40 therapy in AD is still unclarified due to limited controlled trials. |
| تدمد: | 1471-1753 0954-6634 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3363bab8999c31a68085d42c4b600fTest https://doi.org/10.1080/09546634.2021.1914315Test |
| رقم الانضمام: | edsair.doi.dedup.....eb3363bab8999c31a68085d42c4b600f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14711753 09546634 |
|---|