Diagonal earlobe crease (Frank’s sign) and increased risk of cerebrovascular diseases: review of the literature and implications for clinical practice
| العنوان: | Diagonal earlobe crease (Frank’s sign) and increased risk of cerebrovascular diseases: review of the literature and implications for clinical practice |
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| المؤلفون: | Stefano Reggiani, Anna Bersano, Francesco Brigo, Raffaele Nardone, Federico Pacei |
| المصدر: | Neurological Sciences. 41:257-262 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Neurology, Cerebrovascular diseases, Frank’s sign, Dermatology, Diagonal earlobe crease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, otorhinolaryngologic diseases, Humans, Medicine, 030212 general & internal medicine, Ear, External, Earlobe, Neuroradiology, Auricle, Atherosclerosis, Cardiovascular diseases, business.industry, General Medicine, Clinical Practice, Cerebrovascular Disorders, Psychiatry and Mental health, medicine.anatomical_structure, Increased risk, Cardiology, Disease Susceptibility, Neurology (clinical), Neurosurgery, business, 030217 neurology & neurosurgery, Sign (mathematics) |
| الوصف: | Diagonal earlobe crease (DELC) or Frank's sign is a diagonal crease in the earlobe that extends diagonally from the tragus to the edge of the auricle with an angle of approximately 45°. Although its presence increases with advancing age, several studies have shown an independent association between DELC and cardiovascular diseases as well as peripheral vascular diseases. DELC has also been demonstrated to increase the risk of cerebrovascular events (mostly ischaemic stroke), probably through atherosclerotic mechanisms. A systematic literature search was conducted using PubMed and Embase to identify studies investigating the relationship between DELC and the occurrence of cerebrovascular diseases. We identified 5 articles (1469 subjects included). Since the presence of DELC can be easily evaluated, patients with the Frank's sign should undergo a diagnostic workup to detect vascular risk factors and implement preventative therapies. |
| تدمد: | 1590-3478 1590-1874 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae6bb7cc8996e12d0afa6d8daa53523Test https://doi.org/10.1007/s10072-019-04080-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eae6bb7cc8996e12d0afa6d8daa53523 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15903478 15901874 |
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