Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients
| العنوان: | Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients |
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| المؤلفون: | Elaine Coutinho Netto, Carlos Brites, Alfredo Carlos Silva, Celia Pedroso |
| المصدر: | Viruses Viruses, Vol 13, Iss 2223, p 2223 (2021) Volume 13 Issue 11 |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Calcitriol, viruses, vitamin D, Asymptomatic, Gastroenterology, Microbiology, Article, Pathogenesis, Myelopathy, Immune system, immune system diseases, Virology, Internal medicine, hemic and lymphatic diseases, Tropical spastic paraparesis, Vitamin D and neurology, Prevalence, Medicine, Humans, Aged, Inflammation, Human T-lymphotropic virus 1, 25(OH)D, business.industry, virus diseases, Middle Aged, HTLV, medicine.disease, Vitamin D Deficiency, HTLV-I Infections, QR1-502, Paraparesis, Tropical Spastic, Infectious Diseases, Cross-Sectional Studies, Carrier State, Cytokines, Female, medicine.symptom, business, HAM/TSP, Asymptomatic carrier, Brazil, medicine.drug |
| الوصف: | Recent studies have shown the effects of vitamin D on host response to infectious diseases. Some studies detected a high prevalence of hypovitaminosis D in HIV-infected patients, but scarce information exists for HTLV-1 infection. We conducted a cross-sectional study to evaluate the frequency of hypovitaminosis D in HTLV-1 patients and its relationship with their immune response in HTLV-infected patients and in age- and gender-matched controls at a Brazilian rehabilitation hospital. We compared vitamin D, interleukin-6 (IL-6), tumoral necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) levels across groups. Logistic regression was utilized to assess the association between hypovitaminosis D and cytokine levels. We enrolled 161 HTLV-infected subjects (129 HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, 32 asymptomatic HTLV carriers) and equal number of HTLV-negative controls. We observed a significantly higher prevalence of hypovitaminosis D in patients with HAM/TSP than in HTLV asymptomatic carriers (p < 0.001), or controls (p < 0.001). HAM/TSP patients also had higher levels of IL-6 and IFN-γ than asymptomatic carriers. Patients with HAM/TSP and hypovitaminosis D had higher levels of TNF-α than asymptomatic HTLV carriers. These findings suggest hypovitaminosis D plays a role in HAM/TSP pathogenesis, and it needs to be evaluated in further studies. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1999-4915 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2da569c6def21f630962cf38ab161cTest http://europepmc.org/articles/PMC8623239Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ea2da569c6def21f630962cf38ab161c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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