Impact of glycaemic control on fracture risk in 5368 people with newly diagnosed Type 1 diabetes: a time‐dependent analysis
| العنوان: | Impact of glycaemic control on fracture risk in 5368 people with newly diagnosed Type 1 diabetes: a time‐dependent analysis |
|---|---|
| المؤلفون: | Malcolm J Price, Konstantinos A Toulis, S Kumaran, Krishnarajah Nirantharakumar, Rasiah Thayakaran, Parth Narendran, Mary Perrins, Krishna Gokhale |
| المصدر: | Diabetic Medicine. 36:1013-1019 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, Fracture risk, medicine.medical_specialty, Adolescent, Health improvement, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Newly diagnosed, Fractures, Bone, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Risk Factors, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, 030212 general & internal medicine, Child, Retrospective Studies, Glycated Hemoglobin, Type 1 diabetes, Proportional hazards model, business.industry, Hazard ratio, medicine.disease, United Kingdom, Confidence interval, Diabetes Mellitus, Type 1, Treatment Outcome, Increased risk, Female, business |
| الوصف: | AIMS To assess whether glycaemic control is associated with a lifelong increased risk of fracture in people with newly diagnosed Type 1 diabetes. METHODS People with newly diagnosed Type 1 diabetes between 1 January 1995 and 10 May 2016 were identified in The Health Improvement Network database. Longitudinal HbA measurements from diagnosis to fracture or study end or loss to follow-up were collected. A Cox proportional hazards model with HbA included as a time-dependent variable was fitted to these data. RESULTS Some 5368 people with newly diagnosed Type 1 diabetes were included. The estimated adjusted hazard ratio (aHR) for HbA was statistically significant [aHR 1.007; 95% confidence interval (CI) 1.002-1.011 (mmol/mol) and aHR 1.07; 95% CI 1.03-1.12 (%)]. An incremental higher risk of fracture was observed with increasing levels of HbA . CONCLUSIONS In people with newly diagnosed Type 1 diabetes, higher HbA is associated with an increased risk for fractures. This article is protected by copyright. All rights reserved. |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dd2f5c52e891bc28e6524179193acfTest https://doi.org/10.1111/dme.13945Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e9dd2f5c52e891bc28e6524179193acf |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi.dedup.....e9dd2f5c52e891bc28e6524179193acf 856 3 unknown 855.728393554688 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....e9dd2f5c52e891bc28e6524179193acf&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
|
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Impact of glycaemic control on fracture risk in 5368 people with newly diagnosed Type 1 diabetes: a time‐dependent analysis
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Malcolm+J+Price%22">Malcolm J Price</searchLink><br /><searchLink fieldCode="AR" term="%22Konstantinos+A+Toulis%22">Konstantinos A Toulis</searchLink><br /><searchLink fieldCode="AR" term="%22S+Kumaran%22">S Kumaran</searchLink><br /><searchLink fieldCode="AR" term="%22Krishnarajah+Nirantharakumar%22">Krishnarajah Nirantharakumar</searchLink><br /><searchLink fieldCode="AR" term="%22Rasiah+Thayakaran%22">Rasiah Thayakaran</searchLink><br /><searchLink fieldCode="AR" term="%22Parth+Narendran%22">Parth Narendran</searchLink><br /><searchLink fieldCode="AR" term="%22Mary+Perrins%22">Mary Perrins</searchLink><br /><searchLink fieldCode="AR" term="%22Krishna+Gokhale%22">Krishna Gokhale</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <i>Diabetic Medicine</i>. 36:1013-1019 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Wiley, 2019. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2019 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Adult%22">Adult</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+Glucose%22">Blood Glucose</searchLink><br /><searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22Fracture+risk%22">Fracture risk</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Emedical%5Fspecialty%22">medicine.medical_specialty</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescent%22">Adolescent</searchLink><br /><searchLink fieldCode="DE" term="%22Health+improvement%22">Health improvement</searchLink><br /><searchLink fieldCode="DE" term="%22Endocrinology%2C+Diabetes+and+Metabolism%22">Endocrinology, Diabetes and Metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22030209+endocrinology+%26+metabolism%22">030209 endocrinology & metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Newly+diagnosed%22">Newly diagnosed</searchLink><br /><searchLink fieldCode="DE" term="%22Fractures%2C+Bone%22">Fractures, Bone</searchLink><br /><searchLink fieldCode="DE" term="%22Young+Adult%22">Young Adult</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%220302+clinical+medicine%22">0302 clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Endocrinology%22">Endocrinology</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+Factors%22">Risk Factors</searchLink><br /><searchLink fieldCode="DE" term="%22Internal+medicine%22">Internal medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Internal+Medicine%22">Internal Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Hypoglycemic+Agents%22">Hypoglycemic Agents</searchLink><br /><searchLink fieldCode="DE" term="%22030212+general+%26+internal+medicine%22">030212 general & internal medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Child%22">Child</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+Studies%22">Retrospective Studies</searchLink><br /><searchLink fieldCode="DE" term="%22Glycated+Hemoglobin%22">Glycated Hemoglobin</searchLink><br /><searchLink fieldCode="DE" term="%22Type+1+diabetes%22">Type 1 diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22Proportional+hazards+model%22">Proportional hazards model</searchLink><br /><searchLink fieldCode="DE" term="%22business%2Eindustry%22">business.industry</searchLink><br /><searchLink fieldCode="DE" term="%22Hazard+ratio%22">Hazard ratio</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22United+Kingdom%22">United Kingdom</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+interval%22">Confidence interval</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes+Mellitus%2C+Type+1%22">Diabetes Mellitus, Type 1</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+Outcome%22">Treatment Outcome</searchLink><br /><searchLink fieldCode="DE" term="%22Increased+risk%22">Increased risk</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22business%22">business</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => AIMS To assess whether glycaemic control is associated with a lifelong increased risk of fracture in people with newly diagnosed Type 1 diabetes. METHODS People with newly diagnosed Type 1 diabetes between 1 January 1995 and 10 May 2016 were identified in The Health Improvement Network database. Longitudinal HbA measurements from diagnosis to fracture or study end or loss to follow-up were collected. A Cox proportional hazards model with HbA included as a time-dependent variable was fitted to these data. RESULTS Some 5368 people with newly diagnosed Type 1 diabetes were included. The estimated adjusted hazard ratio (aHR) for HbA was statistically significant [aHR 1.007; 95% confidence interval (CI) 1.002-1.011 (mmol/mol) and aHR 1.07; 95% CI 1.03-1.12 (%)]. An incremental higher risk of fracture was observed with increasing levels of HbA . CONCLUSIONS In people with newly diagnosed Type 1 diabetes, higher HbA is associated with an increased risk for fractures. This article is protected by copyright. All rights reserved. ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1464-5491<br />0742-3071 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dd2f5c52e891bc28e6524179193acf" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dd2f5c52e891bc28e6524179193acf</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1111/dme.13945" linkWindow="_blank">https://doi.org/10.1111/dme.13945</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => CLOSED ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....e9dd2f5c52e891bc28e6524179193acf ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 7
[StartPage] => 1013
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Adult
[Type] => general
)
[1] => Array
(
[SubjectFull] => Blood Glucose
[Type] => general
)
[2] => Array
(
[SubjectFull] => Male
[Type] => general
)
[3] => Array
(
[SubjectFull] => Fracture risk
[Type] => general
)
[4] => Array
(
[SubjectFull] => medicine.medical_specialty
[Type] => general
)
[5] => Array
(
[SubjectFull] => Adolescent
[Type] => general
)
[6] => Array
(
[SubjectFull] => Health improvement
[Type] => general
)
[7] => Array
(
[SubjectFull] => Endocrinology, Diabetes and Metabolism
[Type] => general
)
[8] => Array
(
[SubjectFull] => 030209 endocrinology & metabolism
[Type] => general
)
[9] => Array
(
[SubjectFull] => Newly diagnosed
[Type] => general
)
[10] => Array
(
[SubjectFull] => Fractures, Bone
[Type] => general
)
[11] => Array
(
[SubjectFull] => Young Adult
[Type] => general
)
[12] => Array
(
[SubjectFull] => 03 medical and health sciences
[Type] => general
)
[13] => Array
(
[SubjectFull] => 0302 clinical medicine
[Type] => general
)
[14] => Array
(
[SubjectFull] => Endocrinology
[Type] => general
)
[15] => Array
(
[SubjectFull] => Risk Factors
[Type] => general
)
[16] => Array
(
[SubjectFull] => Internal medicine
[Type] => general
)
[17] => Array
(
[SubjectFull] => Internal Medicine
[Type] => general
)
[18] => Array
(
[SubjectFull] => medicine
[Type] => general
)
[19] => Array
(
[SubjectFull] => Humans
[Type] => general
)
[20] => Array
(
[SubjectFull] => Hypoglycemic Agents
[Type] => general
)
[21] => Array
(
[SubjectFull] => 030212 general & internal medicine
[Type] => general
)
[22] => Array
(
[SubjectFull] => Child
[Type] => general
)
[23] => Array
(
[SubjectFull] => Retrospective Studies
[Type] => general
)
[24] => Array
(
[SubjectFull] => Glycated Hemoglobin
[Type] => general
)
[25] => Array
(
[SubjectFull] => Type 1 diabetes
[Type] => general
)
[26] => Array
(
[SubjectFull] => Proportional hazards model
[Type] => general
)
[27] => Array
(
[SubjectFull] => business.industry
[Type] => general
)
[28] => Array
(
[SubjectFull] => Hazard ratio
[Type] => general
)
[29] => Array
(
[SubjectFull] => medicine.disease
[Type] => general
)
[30] => Array
(
[SubjectFull] => United Kingdom
[Type] => general
)
[31] => Array
(
[SubjectFull] => Confidence interval
[Type] => general
)
[32] => Array
(
[SubjectFull] => Diabetes Mellitus, Type 1
[Type] => general
)
[33] => Array
(
[SubjectFull] => Treatment Outcome
[Type] => general
)
[34] => Array
(
[SubjectFull] => Increased risk
[Type] => general
)
[35] => Array
(
[SubjectFull] => Female
[Type] => general
)
[36] => Array
(
[SubjectFull] => business
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Impact of glycaemic control on fracture risk in 5368 people with newly diagnosed Type 1 diabetes: a time‐dependent analysis
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Malcolm J Price
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Konstantinos A Toulis
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => S Kumaran
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Krishnarajah Nirantharakumar
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Rasiah Thayakaran
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Parth Narendran
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Mary Perrins
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Krishna Gokhale
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 05
[M] => 04
[Type] => published
[Y] => 2019
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 14645491
)
[1] => Array
(
[Type] => issn-print
[Value] => 07423071
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsair
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 36
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Diabetic Medicine
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |