Impact of glycaemic control on fracture risk in 5368 people with newly diagnosed Type 1 diabetes: a time‐dependent analysis
| العنوان: | Impact of glycaemic control on fracture risk in 5368 people with newly diagnosed Type 1 diabetes: a time‐dependent analysis |
|---|---|
| المؤلفون: | Malcolm J Price, Konstantinos A Toulis, S Kumaran, Krishnarajah Nirantharakumar, Rasiah Thayakaran, Parth Narendran, Mary Perrins, Krishna Gokhale |
| المصدر: | Diabetic Medicine. 36:1013-1019 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, Fracture risk, medicine.medical_specialty, Adolescent, Health improvement, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Newly diagnosed, Fractures, Bone, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Risk Factors, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, 030212 general & internal medicine, Child, Retrospective Studies, Glycated Hemoglobin, Type 1 diabetes, Proportional hazards model, business.industry, Hazard ratio, medicine.disease, United Kingdom, Confidence interval, Diabetes Mellitus, Type 1, Treatment Outcome, Increased risk, Female, business |
| الوصف: | AIMS To assess whether glycaemic control is associated with a lifelong increased risk of fracture in people with newly diagnosed Type 1 diabetes. METHODS People with newly diagnosed Type 1 diabetes between 1 January 1995 and 10 May 2016 were identified in The Health Improvement Network database. Longitudinal HbA measurements from diagnosis to fracture or study end or loss to follow-up were collected. A Cox proportional hazards model with HbA included as a time-dependent variable was fitted to these data. RESULTS Some 5368 people with newly diagnosed Type 1 diabetes were included. The estimated adjusted hazard ratio (aHR) for HbA was statistically significant [aHR 1.007; 95% confidence interval (CI) 1.002-1.011 (mmol/mol) and aHR 1.07; 95% CI 1.03-1.12 (%)]. An incremental higher risk of fracture was observed with increasing levels of HbA . CONCLUSIONS In people with newly diagnosed Type 1 diabetes, higher HbA is associated with an increased risk for fractures. This article is protected by copyright. All rights reserved. |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dd2f5c52e891bc28e6524179193acfTest https://doi.org/10.1111/dme.13945Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e9dd2f5c52e891bc28e6524179193acf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
|---|