Epidermal Growth Factor Receptor/β-Catenin/T-Cell Factor 4/Matrix Metalloproteinase 1: A New Pathway for Regulating Keratinocyte Invasiveness after UVA Irradiation
| العنوان: | Epidermal Growth Factor Receptor/β-Catenin/T-Cell Factor 4/Matrix Metalloproteinase 1: A New Pathway for Regulating Keratinocyte Invasiveness after UVA Irradiation |
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| المؤلفون: | Loic Ysebaert, Addolorata-Maria-Luce Coluccia, Eric Delabesse, Guy Laurent, Christine Jean, Hélène Hernandez-Pigeon, Marie-José Haure, Amandine Blanc, Marie Charveron, Nais Prade-Houdellier, Talal Al Saati |
| المصدر: | Cancer Research. 69:3291-3299 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Keratinocytes, Cancer Research, Transcription, Genetic, Ultraviolet Rays, Photoaging, Extracellular matrix component, chemistry.chemical_compound, Growth factor receptor, Cell Adhesion, medicine, Humans, Epidermal growth factor receptor, Phosphorylation, beta Catenin, biology, Tyrosine phosphorylation, medicine.disease, ErbB Receptors, medicine.anatomical_structure, Oncology, chemistry, Cancer research, biology.protein, Matrix Metalloproteinase 1, Signal transduction, TCF Transcription Factors, Keratinocyte, Transcription Factor 7-Like 2 Protein, Signal Transduction |
| الوصف: | Previous studies have established that UV irradiation results in epidermal growth factor receptor (EGFR) activation in keratinocytes. However, the signaling pathways and cellular effects related to this process remain incompletely elucidated. Herein, we describe for the first time that UVA-mediated EGFR activation results in β-catenin tyrosine phosphorylation at the Y654 residue responsible for the dissociation of E-cadherin/α-catenin/β-catenin complexes. Moreover, UVA induces an EGFR-dependent, but Wnt-independent, β-catenin relocalization from the membrane to the nucleus followed by its association with T-cell factor 4 (TCF4). This newly formed β-catenin/TCF4 complex binds to a specific site on matrix metalloproteinase 1 (MMP1) promoter and governs MMP1 gene and protein expression, as well as cell migration in collagen and gelatin. Altogether, these results suggest that UVA stimulates keratinocyte invasiveness through two coordinated EGFR-dependent processes: loss of cell-to-cell contact due to β-catenin/E-cadherin/α-catenin dissociation and increased cell migration through extracellular matrix component degradation due to β-catenin/TCF4–dependent MMP1 regulation. These events may represent an important step in epidermis repair following UVA injury and their abnormal regulation could contribute to photoaging and photocarcinogenesis. [Cancer Res 2009;69(8):3291–9] |
| تدمد: | 1538-7445 0008-5472 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c79e1ce7b2fd6eb882d26c8efa9bd7Test https://doi.org/10.1158/0008-5472.can-08-1909Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e9c79e1ce7b2fd6eb882d26c8efa9bd7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
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