CGRP Inhibitors and Oxidative Stress Biomarkers in Resistant Migraine: A Real-Life Study with Erenumab, Fremanezumab, and Galcanezumab
| العنوان: | CGRP Inhibitors and Oxidative Stress Biomarkers in Resistant Migraine: A Real-Life Study with Erenumab, Fremanezumab, and Galcanezumab |
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| المؤلفون: | Sara Gori, Martina Ulivi, Gabriele Siciliano, Michele Papa, Irene Lombardo, Lucia Chico, Sonia Mazzucchi, Ciro De Luca, Letizia Curto, Filippo Baldacci |
| المساهمون: | De Luca, C., Baldacci, F., Mazzucchi, S., Lombardo, I., Curto, L., Ulivi, M., Chico, L., Papa, M., Siciliano, G., Gori, S. |
| المصدر: | Journal of Clinical Medicine Volume 10 Issue 19 Journal of Clinical Medicine, Vol 10, Iss 4586, p 4586 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Medication‐overuse headache, Calcitonin gene-related peptide, medicine.disease_cause, Article, Internal medicine, medicine, oxidative stress, resistant migraine, CGRP, Biomarkers, Oxidative stress, Resistant migraine, Receptor, business.industry, biomarkers, General Medicine, Biomarker, medicine.disease, medication-overuse headache, Allodynia, Migraine, Calcitonin, Anxiety, Biomarker (medicine), Medicine, Oxidative stre, medicine.symptom, business |
| الوصف: | Patients with high-frequency resistant migraine and medication-overuse headache are still the main clinical challenge in tertiary headache centers. The approval of targeted antibodies against the calcitonin gene-related peptide (CGRP) and its receptor represents a powerful instrument. In this study, we observed how biological and clinical features of resistant migraineurs responded to erenumab, fremanezumab, or galcanezumab. We found a reduction in advanced oxidation protein products (AOPP) as a biomarker of improved redox state after six months of treatment. We also found that treatment efficacy was precocious and maintained with high individual responder rates. In particular, seven out of ten patients achieved a reduction of 50% from the baseline at three months, which was maintained at six months, while about one out of our patients experienced a 75% reduction in headache frequency from the first month of treatment. The migraine disability assessment (MIDAS) and the associated fatigue, anxiety, and sleep quality also significantly improved. The allodynia symptom dropped from moderate/severe to mild/absent as a sign of central sensitization reduction. Our study confirmed the safety and efficacy of CGRP inhibition in real-life, high-challenging patients. Additional evidence is needed to understand the role of oxidative stress as a migraine biomarker. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| DOI: | 10.3390/jcm10194586 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9564a9fc2cfa8a3e146621b50ee8d85Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e9564a9fc2cfa8a3e146621b50ee8d85 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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| DOI: | 10.3390/jcm10194586 |