Cyclic Imines: Chemistry and Mechanism of Action: A Review
| العنوان: | Cyclic Imines: Chemistry and Mechanism of Action: A Review |
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| المؤلفون: | Ana G. Cabado, Alberto Otero, María-José Chapela, Juan M. Vieites, Miroslava Atanassova |
| المصدر: | Chemical Research in Toxicology. 24:1817-1829 |
| بيانات النشر: | American Chemical Society (ACS), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Double bond, Cell Survival, Stereochemistry, Imine, Hydrocarbons, Cyclic, Food Contamination, Ether, Muscarinic Antagonists, Nicotinic Antagonists, Receptors, Nicotinic, Toxicology, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Microalgae, medicine, Animals, Humans, Shellfish Poisoning, Structure–activity relationship, Bioassay, Spiro Compounds, Pyrans, Shellfish, chemistry.chemical_classification, Binding Sites, General Medicine, medicine.disease, Receptors, Muscarinic, Shellfish poisoning, chemistry, Biochemistry, Mechanism of action, Toxicity, Biological Assay, Marine Toxins, Imines, medicine.symptom, Heterocyclic Compounds, 3-Ring, Injections, Intraperitoneal, Protein Binding |
| الوصف: | In recent years, there has been an increase in the production of shellfish and in global demand for seafood as nutritious and healthy food. Unfortunately, a significant number of incidences of shellfish poisoning occur worldwide, and microalgae that produce phycotoxins are responsible for most of these. Phycotoxins include several groups of small to medium sized natural products with molecular masses ranging from 300 to over 3000 Da. Cyclic imines (CIs) are a recently discovered group of marine biotoxins characterized by their fast acting toxicity, inducing a characteristic rapid death in the intraperitoneal mouse bioassay. These toxins are macrocyclic compounds with imine (carbon-nitrogen double bond) and spiro-linked ether moieties. They are grouped together due to the imino group functioning as their common pharmacore and due to the similarities in their intraperitoneal toxicity in mice. Spirolides (SPXs) are the largest group of CIs cyclic imines that together with gymnodimines (GYMs) are best characterized. Although the amount of cyclic imines in shellfish is not regulated and these substances have not been categorically linked to human intoxication, they trigger high intraperitoneal toxicity in rodents. In this review, the corresponding chemical structures of each member of the CIs and their derivatives are reviewed as well as all the data accumulated on their mechanism of action at cellular level. |
| تدمد: | 1520-5010 0893-228X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8da58331ef9c07ee2fd3ba1d6542ef9Test https://doi.org/10.1021/tx200182mTest |
| رقم الانضمام: | edsair.doi.dedup.....e8da58331ef9c07ee2fd3ba1d6542ef9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205010 0893228X |
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