GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake
| العنوان: | GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake |
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| المؤلفون: | Laura E. Rupprecht, Matthew R. Hayes, Amber L. Alhadeff |
| المصدر: | Endocrinology. 153:647-658 |
| بيانات النشر: | The Endocrine Society, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, endocrine system, medicine.medical_specialty, Central nervous system, Nucleus accumbens, Biology, Glucagon-Like Peptide-1 Receptor, Nucleus Accumbens, Rats, Sprague-Dawley, Eating, Endocrinology, Glucagon-Like Peptide 1, Internal medicine, Receptors, Glucagon, Solitary Nucleus, medicine, Animals, Hypoglycemic Agents, Neurons, Dose-Response Relationship, Drug, Venoms, Energy Balance-Obesity, Solitary nucleus, Ventral Tegmental Area, digestive, oral, and skin physiology, Solitary tract, Glucagon-like peptide-1, Rats, Ventral tegmental area, medicine.anatomical_structure, Gene Expression Regulation, nervous system, Exenatide, Neuron, Peptides, Nucleus, hormones, hormone substitutes, and hormone antagonists, Signal Transduction |
| الوصف: | Central glucagon-like-peptide-1 (GLP-1) receptor activation reduces food intake; however, brain nuclei and mechanism(s) mediating this effect remain poorly understood. Although central nervous system GLP-1 is produced almost exclusively in the nucleus of the solitary tract in the hindbrain, GLP-1 receptors (GLP-1R) are expressed throughout the brain, including nuclei in the mesolimbic reward system (MRS), e.g. the ventral tegmental area (VTA) and the nucleus accumbens (NAc). Here, we examine the MRS as a potential site of action for GLP-1-mediated control of food intake and body weight. Double immunohistochemistry for Fluorogold (monosynaptic retrograde tracer) and GLP-1 neuron immunoreactivity indicated that GLP-1-producing nucleus tractus solitarius neurons project directly to the VTA, the NAc core, and the NAc shell. Pharmacological data showed that GLP-1R activation in the VTA, NAc core, and NAc shell decreased food intake, especially of highly-palatable foods, and body weight. Moreover, blockade of endogenous GLP-1R signaling in the VTA and NAc core resulted in a significant increase in food intake, establishing a physiological relevance for GLP-1 signaling in the MRS. Current data highlight these nuclei within the MRS as novel sites for GLP-1R-mediated control of food intake and body weight. |
| تدمد: | 1945-7170 0013-7227 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a48518fe265f91516bb9dc6104ca74Test https://doi.org/10.1210/en.2011-1443Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e8a48518fe265f91516bb9dc6104ca74 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457170 00137227 |
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