Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial
| العنوان: | Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial |
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| المؤلفون: | Kenechukwu Chudy-Onwugaje, Lingxiao Wang, Mark P. Purdue, Christine Cole Johnson, Sonja I. Berndt, L. Joseph Su, Wen-Yi Huang, Kathryn Hughes Barry, Hormuzd A. Katki |
| المصدر: | Cancer |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adenoma, Male, Cancer Research, medicine.medical_specialty, Colorectal cancer, Population, Ibuprofen, Colorectal adenoma, Gastroenterology, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Cancer screening, medicine, Humans, Prospective Studies, 030212 general & internal medicine, education, Early Detection of Cancer, Aged, education.field_of_study, Aspirin, business.industry, Incidence, Hazard ratio, Cancer, medicine.disease, Oncology, 030220 oncology & carcinogenesis, Female, Colorectal Neoplasms, business, medicine.drug |
| الوصف: | BACKGROUND Studying the differential impact of aspirin and other nonsteroidal anti-inflammatory drugs across the stages of colorectal neoplasia from early adenoma to cancer is critical for understanding the benefits of these widely used drugs. METHODS With 13 years of follow-up, the authors prospectively evaluated the association between aspirin and ibuprofen use and incident distal adenoma (1221 cases), recurrent adenoma (862 cases), and incident colorectal cancer (CRC; 2826 cases) among men and women in the population-based Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. With multivariable-adjusted models, odds ratio (ORs) and 95% confidence intervals (CIs) for adenoma incidence and recurrence and hazard ratios (HRs) and 95% CIs for incident CRC were determined. RESULTS The authors observed a significantly reduced risk of incident adenoma with ibuprofen use (≥30 vs |
| تدمد: | 1097-0142 0008-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8425df19bb33d8e16eee9fada8d1246Test https://doi.org/10.1002/cncr.33623Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e8425df19bb33d8e16eee9fada8d1246 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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