A Risk Model for Predicting Fetuses with Trisomy 21 Using Alpha-Fetoprotein Variants L2 Combined with Maternal Serum Biomarkers in Early Pregnancy
| العنوان: | A Risk Model for Predicting Fetuses with Trisomy 21 Using Alpha-Fetoprotein Variants L2 Combined with Maternal Serum Biomarkers in Early Pregnancy |
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| المؤلفون: | Yijie Chen, Huimin Zhang, Yiming Chen, Wenwen Ning, Bin Wu |
| المصدر: | Reproductive Sciences. 29:1287-1295 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.drug_class, Trisomy, Gastroenterology, Fetus, Pregnancy, Serum biomarkers, Prenatal Diagnosis, Internal medicine, medicine, Humans, Pregnancy-Associated Plasma Protein-A, Chorionic Gonadotropin, beta Subunit, Human, Retrospective Studies, business.industry, Area under the curve, Obstetrics and Gynecology, medicine.disease, Blood proteins, Pregnancy Trimester, First, Case-Control Studies, Biomarker (medicine), Female, alpha-Fetoproteins, Down Syndrome, Gonadotropin, business, Alpha-fetoprotein, Biomarkers |
| الوصف: | To establish a risk prediction model and the clinical value of trisomy 21 using alpha-fetoprotein variants L2 (AFP-L2) combined with maternal serum biomarkers and nuchal translucency (NT) thickness in early pregnancy. A retrospective case–control study was conducted. The subjects were divided into the case group (n = 40) or the control group (n = 40). An enzyme-linked immunosorbent assay was used to measure the maternal serum AFP-L2 level in both groups. The AFP-L2 single-index or multi-index combined risk model was used to predict the efficiency of trisomy 21. The best cut-off value and area under the curve (AUC) were determined to evaluate the predictive efficacy of different risk models constructed by AFP-L2. The maternal serum AFP-L2 level in the case group was 1.59 (0.61–3.61) Multiple of medium (MoM), which was higher than 1.00 (0.39–2.12) MoM in the control group (P P P |
| تدمد: | 1933-7205 1933-7191 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ea7dbae52748ffa16d6b0e36caba77Test https://doi.org/10.1007/s43032-021-00762-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e7ea7dbae52748ffa16d6b0e36caba77 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19337205 19337191 |
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