Hypertension Contributes to Neuropathy in Patients With Type 1 Diabetes
| العنوان: | Hypertension Contributes to Neuropathy in Patients With Type 1 Diabetes |
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| المؤلفون: | Nathan Efron, Ioannis N. Petropoulos, Maryam Ferdousi, Georgios Ponirakis, Andrew J.M. Boulton, Shazli Azmi, Hitoshi Nukada, Rayaz A. Malik, Maria Jeziorska, Omar Asghar, Uazman Alam, Andrew Marshall, Ziyad Mahfoud |
| المصدر: | American Journal of Hypertension Ponirakis, G, Petropoulos, I N, Alam, U, Ferdousi, M, Asghar, O, Marshall, A, Azmi, S, Jeziorska, M, Mahfoud, Z R, Boulton, A J M, Efron, N, Nukada, H & Malik, R A 2019, ' Hypertension contributes to neuropathy in patients with type 1 diabetes ', American Journal of Hypertension, vol. 32, no. 8, pp. 796-803 . https://doi.org/10.1093/ajh/hpz058Test |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Original Contributions, medicine.medical_treatment, Neural Conduction, Action Potentials, quantitative sensory testing, Nerve conduction velocity, Cornea, Diabetes And Metabolic Syndrome, Nerve Fibers, 0302 clinical medicine, Diabetic Neuropathies, Risk Factors, blood pressure, Middle Aged, 3. Good health, Compound muscle action potential, Touch Perception, Hypertension, Blood pressure, corneal confocal microscopy, Cardiology, Female, Adult, medicine.medical_specialty, hypertension, 030209 endocrinology & metabolism, 03 medical and health sciences, Vibration perception, Nerve conduction, quantitative sensory testing, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, nerve conduction, Type 1 diabetes, business.industry, diabetic peripheral neuropathy, medicine.disease, Diabetic peripheral neuropathy, Diabetes Mellitus, Type 1, Peripheral neuropathy, Amputation, Corneal confocal microscopy, Case-Control Studies, Tibial Nerve, business, 030217 neurology & neurosurgery |
| الوصف: | BACKGROUND Diabetic peripheral neuropathy (DPN) can lead to foot ulceration and amputation. There are currently no disease-modifying therapies for DPN. The aim of this study was to determine if hypertension contributes to DPN in patients with type 1 diabetes mellitus (T1DM). METHODS Subjects with T1DM (n = 70) and controls (n = 78) underwent a comprehensive assessment of DPN. RESULTS Hypertension was present in 40 of 70 T1DM subjects and 20 of 78 controls. Hypertension was associated with abnormal nerve conduction parameters (P = 0.03 to CONCLUSIONS This study shows that hypertension is associated with impaired nerve conduction in T1DM. It supports previous small trials showing that angiotensin-converting enzyme inhibitors improve nerve conduction and advocates the need for larger clinical trials with blood pressure lowering agents in DPN. |
| تدمد: | 1941-7225 0895-7061 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74ea267f548a4c80608beb5603e7531Test https://doi.org/10.1093/ajh/hpz058Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e74ea267f548a4c80608beb5603e7531 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19417225 08957061 |
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