Autocrine FGF1 signaling promotes glucose uptake in adipocytes
| العنوان: | Autocrine FGF1 signaling promotes glucose uptake in adipocytes |
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| المؤلفون: | Vera J. M. Nies, Dicky Struik, Sihao Liu, Weilin Liu, Janine K. Kruit, Michael Downes, Tim van Zutphen, Henkjan J. Verkade, Ronald M. Evans, Johan W. Jonker |
| المساهمون: | Center for Liver, Digestive and Metabolic Diseases (CLDM), Health & Food |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America, 119(40):e2122382119. NATL ACAD SCIENCES |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adipose Tissue, White/metabolism, Insulin/metabolism, Adipose Tissue, White, Fibroblast Growth Factor/metabolism, Mice, Glucose Transporter Type 4/genetics, 3T3-L1 Cells, Receptors, Proto-Oncogene Proteins c-akt/metabolism, Adipocytes, Glucose/metabolism, Animals, Insulin, Glucose Transporter Type 1/genetics, Glucose Transporter Type 1, Glucose Transporter Type 4, Multidisciplinary, Receptors, Fibroblast Growth Factor/metabolism, Receptors, Fibroblast Growth Factor, White/metabolism, Glucose, Adipose Tissue, Adipocytes/metabolism, Fibroblast Growth Factor 1, Proto-Oncogene Proteins c-akt, Fibroblast Growth Factor 1/genetics |
| الوصف: | Fibroblast growth factor 1 (FGF1) is an autocrine growth factor released from adipose tissue during over-nutrition or fasting to feeding transition. While local actions underlie the majority of FGF1’s anti-diabetic functions, the molecular mechanisms downstream of adipose FGF receptor signaling are unclear. We investigated the effects of FGF1 on glucose uptake and its underlying mechanism in murine 3T3-L1 adipocytes and in ex vivo adipose explants from mice. FGF1 increased glucose uptake in 3T3-L1 adipocytes and epididymal WAT (eWAT) and inguinal WAT (iWAT). Conversely, glucose uptake was reduced in eWAT and iWAT of FGF1 knockout mice. We show that FGF1 acutely increased adipocyte glucose uptake via activation of the insulin-sensitive glucose transporter GLUT4, involving dynamic crosstalk between the MEK1/2 and Akt signaling proteins. Prolonged exposure to FGF1 stimulated adipocyte glucose uptake by MEK1/2-dependent transcription of the basal glucose transporter GLUT1. We have thus identified an alternative pathway to stimulate glucose uptake in adipocytes, independent from insulin, which could open new avenues for treating patients with type 2 diabetes. |
| وصف الملف: | application/pdf |
| تدمد: | 1091-6490 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e743138547b0be6aab799b2becc0b11cTest https://doi.org/10.1073/pnas.2122382119Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e743138547b0be6aab799b2becc0b11c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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