Role of pHi, and proton transporters in oncogene-driven neoplastic transformation
| العنوان: | Role of pHi, and proton transporters in oncogene-driven neoplastic transformation |
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| المؤلفون: | Stephan J. Reshkin, Rosa Angela Cardone, Maria Raffaella Greco |
| المصدر: | Philosophical Transactions of the Royal Society B: Biological Sciences. 369:20130100 |
| بيانات النشر: | The Royal Society, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Cytoplasm, Sodium-Hydrogen Exchangers, Oncogene Proteins, Cell, medicine.disease_cause, Models, Biological, General Biochemistry, Genetics and Molecular Biology, medicine, Humans, Neoplastic transformation, Cation Transport Proteins, Sodium-Hydrogen Exchanger 1, Oncogene, Chemistry, Cancer, Oncogenes, Articles, Hydrogen-Ion Concentration, Proton Pumps, medicine.disease, Cell biology, Cell Transformation, Neoplastic, medicine.anatomical_structure, Cancer cell, General Agricultural and Biological Sciences, Carcinogenesis, Intracellular |
| الوصف: | The change of a normal, healthy cell to a transformed cell is the first step in the evolutionary arc of a cancer. While the role of oncogenes in this ‘passage’ is well known, the role of ion transporters in this critical step is less known and is fundamental to our understanding the early physiological processes of carcinogenesis. Cancer cells and tissues have an aberrant regulation of hydrogen ion dynamics leading to a reversal of the normal tissue intracellular to extracellular pH gradient (ΔpHito ΔpHe). When this perturbation in pH dynamics occurs during carcinogenesis is less clear. Very early studies using the introduction of different oncogene proteins into cells observed a concordance between neoplastic transformation and a cytoplasmic alkalinization occurring concomitantly with a shift towards glycolysis in the presence of oxygen, i.e. ‘Warburg metabolism’. These processes may instigate a vicious cycle that drives later progression towards fully developed cancer where the reversed pH gradient becomes ever more pronounced. This review presents our understanding of the role of pH and the NHE1 in driving transformation, in determining the first appearance of the cancer ‘hallmark’ characteristics and how the use of pharmacological approaches targeting pH/NHE1 may open up new avenues for efficient treatments even during the first steps of cancer development. |
| تدمد: | 1471-2970 0962-8436 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6af17d61dce01a81d57f0193201476fTest https://doi.org/10.1098/rstb.2013.0100Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e6af17d61dce01a81d57f0193201476f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712970 09628436 |
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