Immune reconstruction effectiveness of combination antiretroviral therapy for HIV-1 CRF01_AE cluster 1 and 2 infected individuals
| العنوان: | Immune reconstruction effectiveness of combination antiretroviral therapy for HIV-1 CRF01_AE cluster 1 and 2 infected individuals |
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| المؤلفون: | Kang Li, Huanhuan Chen, Jianjun Li, Yi Feng, Guanghua Lan, Shujia Liang, Meiliang Liu, Abdur Rashid, Hui Xing, Zhiyong Shen, Yiming Shao |
| المصدر: | Emerging Microbes & Infections article-version (VoR) Version of Record Emerging Microbes and Infections, Vol 11, Iss 1, Pp 158-167 (2022) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, CD4-Positive T-Lymphocytes, Male, Receptors, CXCR4, Genotype, Epidemiology, Anti-HIV Agents, Immunology, antiretroviral therapy, HIV Infections, Infectious and parasitic diseases, RC109-216, HIV Envelope Protein gp120, Microbiology, coreceptor tropism, Immune Reconstitution, Virology, Antiretroviral Therapy, Highly Active, Drug Discovery, Humans, Retrospective Studies, genetic sub-cluster, virus diseases, General Medicine, Middle Aged, QR1-502, Peptide Fragments, CD4 Lymphocyte Count, immune reconstruction, Viral Tropism, Infectious Diseases, HIV-1, Parasitology, Female, Research Article |
| الوصف: | There are great disparities of the results in immune reconstruction (IR) of the HIV-1 infected patients during combined antiretroviral therapy (cART), due to both host polymorphisms and viral genetic subtypes. Identifying these factors and elucidating their impact on the IR could help to improve the efficacy. To study the factors influencing the IR, we conducted a 15-year retrospective cohort study of HIV-1 infected individuals under cART. The trend of CD4+ count changes was evaluated by the generalized estimating equations. Cox proportional model and propensity score matching were used to identify variables that affect the possibility of achieving IR. The tropism characteristics of virus were compared using the coreceptor binding model. In addition to baseline CD4+ counts and age implications, CRF01_AE cluster 1 was associated with a poorer probability of achieving IR than infection with cluster 2 (aHR, 1.39; 95%CI, 1.02-1.90) and other subtypes (aHR, 1.83; 95%CI, 1.31-2.56). The mean time from cART initiation to achieve IR was much longer in patients infected by CRF01_AE cluster 1 than other subtypes/sub-clusters (P |
| تدمد: | 2222-1751 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e621126de395550ab19b4a054ba37ff8Test https://pubmed.ncbi.nlm.nih.gov/34895083Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e621126de395550ab19b4a054ba37ff8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22221751 |
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