Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma
العنوان: | Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma |
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المؤلفون: | Nicola Baldini, Katia Scotlandi, G. Bacci, Franco Bertoni, Stefania Benini, M.C. Manara, Giuseppe Barbanti-Brodano, S. Sottili, Massimo Serra, Piero Picci, Daniela Maurici |
المصدر: | International Journal of Oncology. |
بيانات النشر: | Spandidos Publications, 1999. |
سنة النشر: | 1999 |
مصطلحات موضوعية: | Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Adolescent, Tumor suppressor gene, Bone Neoplasms, Biomarkers, Tumor, medicine, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Neoplasm Metastasis, Child, neoplasms, Regulation of gene expression, Osteosarcoma, Oncogene, biology, Cell cycle, Prognosis, medicine.disease, Molecular medicine, Gene Expression Regulation, Neoplastic, Oncology, biology.protein, Cancer research, Mdm2, Immunohistochemistry, Female, Tumor Suppressor Protein p53 |
الوصف: | The transcription of MDR1 gene may be increased by mutation or loss of function of p53 gene. In this study, we investigated whether in osteosarcoma, the p53 status is correlated with overexpression of the MDR1 gene product P-glycoprotein. The relationship between P-glycoprotein expression and p53 status was analyzed by immunohistochemistry in 64 primary and 11 metastatic high-grade osteosarcomas. In the same series, we also assessed the nuclear accumulation of MDM2 protein, whose binding to p53 protein provides an alternative mechanism of p53 inactivation. No association was found between mutant-p53 and MDM2 nuclear accumulation either with P-glycoprotein expression or with clinical course. Only increased expression of P-glycoprotein in tumor cells was significantly associated with a poor outcome, further supporting the adverse prognostic value of this marker in osteosarcoma. |
تدمد: | 1791-2423 1019-6439 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e618f54d9dec407d99637c2595627bafTest https://doi.org/10.3892/ijo.14.2.301Test |
رقم الانضمام: | edsair.doi.dedup.....e618f54d9dec407d99637c2595627baf |
قاعدة البيانات: | OpenAIRE |
تدمد: | 17912423 10196439 |
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