Glucose transporter 1 (GLUT1) expression is associated with intestinal type of gastric carcinoma
| العنوان: | Glucose transporter 1 (GLUT1) expression is associated with intestinal type of gastric carcinoma |
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| المؤلفون: | Young Youl Kim, Se Jin Jang, Myeong Ho Jung, Kuchan Kimm, Wan Seop Kim |
| المصدر: | Journal of Korean Medical Science |
| بيانات النشر: | Korean Academy of Medical Sciences, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, Pathology, medicine.medical_specialty, Monosaccharide Transport Proteins, Adenocarcinoma, Stomach Neoplasms, Metaplasia, Biomarkers, Tumor, medicine, Gastric mucosa, Humans, Aged, Glucose Transporter Type 1, biology, Reverse Transcriptase Polymerase Chain Reaction, Glucose transporter, nutritional and metabolic diseases, Intestinal metaplasia, Cancer, General Medicine, Middle Aged, medicine.disease, digestive system diseases, Neoplasm Proteins, Intestines, carbohydrates (lipids), medicine.anatomical_structure, Gastric Mucosa, biology.protein, Female, GLUT1, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, Immunostaining, Research Article |
| الوصف: | Increased expression of glucose transporter1 (GLUT1) has been reported in many human cancers. We hypothesized that the degree of GLUT1 might provide a useful biological information in gastric adenocarcinoma. RT-PCR and immunostaining were used to analyze GLUT1 expression in gastric cancer. RT-PCR showed GLUT1 expression was not largely detected in normal gastric tissue but was detected in cancerous gastric tissue of counterpart. By immunohistochemistry, GLUT1 protein was absent in normal gastric epithelium and intestinal metaplasia. 11 of 65 patients with gastric adenocarcinoma had specific GLUT1 immunostaining in a plasma membrane pattern with varied intensities. GLUT1 protein did not show any significant correlation with tumor stage and nodal metastasis (p>0.05 by Mann-Whitney test). However, the positive immunostaining for GLUT1 is associated with intestinal differentiation (p=0.003). Our results suggest that GLUT1 protein is associated with intestinal type of gastric cancer. |
| تدمد: | 1598-6357 1011-8934 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54584c00d486164925c7d997ef9fe4cTest https://doi.org/10.3346/jkms.2000.15.4.420Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e54584c00d486164925c7d997ef9fe4c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15986357 10118934 |
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