Relationship between ABO blood groups and von Willebrand factor, ADAMTS13 and factor VIII in patients undergoing hemodialysis
| العنوان: | Relationship between ABO blood groups and von Willebrand factor, ADAMTS13 and factor VIII in patients undergoing hemodialysis |
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| المؤلفون: | Maria da Gloria Carvalho, Luci Maria Sant'Ana Dusse, Ana Paula Fernandes, Cláudia N. Ferreira, Ana Cristina Simões e Silva, Danyelle Romana Alves Rios, Karina Braga Gomes, Daniela Amorim Melgaço Guimarães, Roberta Carvalho de Figueiredo |
| المصدر: | Journal of Thrombosis and Thrombolysis. 33:416-421 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Adolescent, medicine.medical_treatment, ADAMTS13 Protein, Gastroenterology, ABO Blood-Group System, Antigen, Von Willebrand factor, Renal Dialysis, Risk Factors, hemic and lymphatic diseases, Internal medicine, ABO blood group system, von Willebrand Factor, medicine, Humans, Risk factor, Aged, Factor VIII, Hematology, biology, business.industry, Thrombosis, Middle Aged, medicine.disease, ADAMTS13, ADAM Proteins, Cross-Sectional Studies, Immunology, biology.protein, Female, Hemodialysis, Cardiology and Cardiovascular Medicine, business, Biomarkers |
| الوصف: | Several studies have demonstrated that non-O blood groups subjects present an increased VTE risk as compared to those carrying O blood group. The aim of this study was to investigate the ABO blood groups influence on factor VIII (FVIII) activity, von Willebrand factor (VWF), and ADAMTS13 plasma levels in patients undergoing hemodialysis (HD). Patients undergoing HD (N=195) and 80 healthy subjects (control group) were eligible for this cross-sectional study. The ABO blood group phenotyping was performed by the reverse technique. FVIII activity was measured through coagulometric method, and VWF and ADAMTS13 antigens were assessed by ELISA. FVIII activity and VWF levels were significantly higher and ADAMTS13 levels was decreased in HD patients, as compared to healthy subjects (P < 0.001, in three cases). HD patients carrying non-O blood groups showed a significant increase in FVIII activity (P = 0.001) and VWF levels (P < 0.001) when compared to carriers of O blood group. However, no significant difference was observed in ADAMTS13 levels (P = 0.767). In the control group, increased in FVIII activity (P = 0.001) and VWF levels (P = 0.002) and decreased in ADAMTS13 levels (P = 0.005) were observed in subjects carrying non-O blood groups as compared to carriers of O blood group.Our data confirmed that ABO blood group is an important risk factor for increased procoagulant factors in plasma, as FVIII and VWF. Admitting the possible role of kidneys in ADAMTS13 synthesis or on its metabolism, HD patients were not able to increase ADAMTS13 levels in order to compensate the increase of VWF levels mediated by ABO blood groups. Considering that non-O blood groups constitute a risk factor for thrombosis, it is reasonable to admit that A, B and AB HD patients need a careful and continuous follow-up in order to minimize thrombotic events. |
| تدمد: | 1573-742X 0929-5305 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4aa9b41195330dcc3744f40b1b0012cTest https://doi.org/10.1007/s11239-012-0719-5Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e4aa9b41195330dcc3744f40b1b0012c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1573742X 09295305 |
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