Glycation and Carboxymethyllysine Levels in Skin Collagen Predict the Risk of Future 10-Year Progression of Diabetic Retinopathy and Nephropathy in the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications Participants With Type 1 Diabetes
| العنوان: | Glycation and Carboxymethyllysine Levels in Skin Collagen Predict the Risk of Future 10-Year Progression of Diabetic Retinopathy and Nephropathy in the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications Participants With Type 1 Diabetes |
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| المؤلفون: | David R. Sell, Wanjie Sun, Patricia A. Cleary, Vincent M. Monnier, William Dahms, John I. Malone, William I. Sivitz, Saul Genuth |
| المصدر: | Diabetes. 54:3103-3111 |
| بيانات النشر: | American Diabetes Association, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Glycation End Products, Advanced, Male, medicine.medical_specialty, Time Factors, Biopsy, Endocrinology, Diabetes and Metabolism, Gastroenterology, Article, Nephropathy, Glycation, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Diabetic Nephropathies, Risk factor, Skin, Type 1 diabetes, Diabetic Retinopathy, business.industry, Lysine, Diabetic retinopathy, Prognosis, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, Disease Progression, Female, Collagen, Disease Susceptibility, business, Kidney disease, Retinopathy |
| الوصف: | Several mechanistic pathways linking hyperglycemia to diabetes complications, including glycation of proteins and formation of advanced glycation end products (AGEs), have been proposed. We investigated the hypothesis that skin collagen glycation and AGEs predict the risk of progression of microvascular disease. We measured glycation products in the skin collagen of 211 Diabetes Control and Complications Trial (DCCT) volunteers in 1992 who continued to be followed in the Epidemiology of Diabetes Interventions and Complications study for 10 years. We determined whether the earlier measurements of glycated collagen and AGE levels correlated with the risk of progression of retinopathy and nephropathy from the end of the DCCT to 10 years later. In multivariate analyses, the combination of furosine (glycated collagen) and carboxymethyllysine (CML) predicted the progression of retinopathy (χ2 = 59.4, P < 0.0001) and nephropathy (χ2 = 18.2, P = 0.0001), even after adjustment for mean HbA1c (A1C) (χ2 = 32.7, P < 0.0001 for retinopathy) and (χ2 = 12.8, P = 0.0016 for nephropathy). The predictive effect of A1C vanished after adjustment for furosine and CML (χ2 = 0.0002, P = 0.987 for retinopathy and χ2 = 0.0002, P = 0.964 for nephropathy). Furosine explained more of the variation in the 10-year progression of retinopathy and nephropathy than did CML. These results strengthen the role of glycation of proteins and AGE formation in the pathogenesis of retinopathy and nephropathy. Glycation and subsequent AGE formation may explain the risk of these complications associated with prior A1C and provide a rational basis for the phenomenon of “metabolic memory” in the pathogenesis of these diabetes complications. |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a09c17a54706839f2ce32d4f5f7e88Test https://doi.org/10.2337/diabetes.54.11.3103Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e4a09c17a54706839f2ce32d4f5f7e88 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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