Modulation of cell signalling and sulfation in cardiovascular development and disease
| العنوان: | Modulation of cell signalling and sulfation in cardiovascular development and disease |
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| المؤلفون: | Antonie Martiniuc, Gurtej K. Dhoot, Tiago Justo |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cell signaling, Cell biology, Science, Ischemia, Myocardial Infarction, Biology, Article, Cell Line, Mice, Dogs, SULF1, Transforming Growth Factor beta, medicine, Animals, Humans, Receptor, Cancer, Fetus, Multidisciplinary, Myocardium, Biological techniques, Endothelial Cells, Heart, Hypoxia (medical), medicine.disease, In vitro, Cell Hypoxia, Endothelial stem cell, Disease Models, Animal, Medicine, medicine.symptom, Sulfatases, Sulfotransferases, Signal Transduction |
| الوصف: | Sulf1/Sulf2 genes are highly expressed during early fetal cardiovascular development but down-regulated during later stages correlating with a number of cell signalling pathways in a positive or a negative manner. Immunocytochemical analysis confirmed SULF1/SULF2 expression not only in endothelial cell lining of blood vessels but also in the developing cardiomyocytes but not in the adult cardiomyocytes despite persisting at reduced levels in the adult endothelial cells. The levels of both SULFs in adult ischemic human hearts and in murine hearts following coronary occlusion increased in endothelial lining of some regional blood vessels but with little or no detection in the cardiomyocytes. Unlike the normal adult heart, the levels of SULF1 and SULF2 were markedly increased in the adult canine right-atrial haemangiosarcoma correlating with increased TGFβ cell signalling. Cell signalling relationship to ischaemia was further confirmed by in vitro hypoxia of HMec1 endothelial cells demonstrating dynamic changes in not only vegf and its receptors but also sulfotransferases and Sulf1 & Sulf2 levels. In vitro hypoxia of HMec1 cells also confirmed earlier up-regulation of TGFβ cell signalling revealed by Smad2, Smad3, ALK5 and TGFβ1 changes and later down-regulation correlating with Sulf1 but not Sulf2 highlighting Sulf1/Sulf2 differences in endothelial cells under hypoxia. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47eba9d44d056c1e68f0a0bfc6f22c0Test https://doaj.org/article/8fb1d03a4c0d41338b056f8899ca9223Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e47eba9d44d056c1e68f0a0bfc6f22c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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