Nuclear inclusions in spinocerebellar ataxia type 1
| العنوان: | Nuclear inclusions in spinocerebellar ataxia type 1 |
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| المؤلفون: | Géraldine Cancel, Charles Duyckaerts, Alexis Brice, Alexandra Durr |
| المصدر: | Acta Neuropathologica. 97:201-207 |
| بيانات النشر: | Springer Science and Business Media LLC, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Adult, Male, Spinocerebellar Ataxia Type 1, Pathology, medicine.medical_specialty, Biology, Antibodies, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Fatal Outcome, medicine, Humans, Ubiquitins, Spinocerebellar Degenerations, Cell Nucleus, Inclusion Bodies, Neurons, Microscopy, Confocal, Histocytochemistry, Brain, medicine.disease, Immunohistochemistry, Pedigree, Congo red, Cell nucleus, medicine.anatomical_structure, Spinal Cord, nervous system, chemistry, Spinocerebellar ataxia, biology.protein, Neurology (clinical), Antibody, Trinucleotide Repeat Expansion, Ethidium bromide, Trinucleotide repeat expansion |
| الوصف: | Spinocerebellar ataxia type 1 is due to a CAG repeat expansion in the gene encoding ataxin-1. In a case with an expansion of 56 repeats, intranuclear inclusions were found only in neurons, both in severely affected regions (such as the pons) and in areas where the lesions were inconspicuous (such as the cortex or the striatum). The inclusions were labelled by a monoclonal antibody directed against long polyglutamine stretches (1C2); they were also detected by the anti-ubiquitin antibody. They were faintly eosinophilic, Congo red negative and were not stained by thioflavin S or by ethidium bromide. |
| تدمد: | 1432-0533 0001-6322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e435e2fafe4b01f159332c0e05ac04d0Test https://doi.org/10.1007/s004010050975Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e435e2fafe4b01f159332c0e05ac04d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320533 00016322 |
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