Serum lactate dehydrogenase is a possible predictor of platinum resistance in ovarian cancer
| العنوان: | Serum lactate dehydrogenase is a possible predictor of platinum resistance in ovarian cancer |
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| المؤلفون: | Asami Ikeda, Kenji Takakura, Kaoru Abiko, Ken Yamaguchi, Ikuo Konishi, Noriko Satoh-Asahara, Hajime Yamakage |
| المصدر: | Obstetrics & Gynecology Science, Vol 63, Iss 6, Pp 709-718 (2020) Obstetrics & Gynecology Science |
| بيانات النشر: | Korean Society of Obstetrics and Gynecology, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Lymphocyte, medicine.medical_treatment, chemotherapy, Gastroenterology, lcsh:Gynecology and obstetrics, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Lactate dehydrogenase, Medicine, platinum, Neutrophil to lymphocyte ratio, lcsh:RG1-991, Chemotherapy, 030219 obstetrics & reproductive medicine, business.industry, Area under the curve, Obstetrics and Gynecology, Cancer, lactate dehydrogenase, Gynecologic Oncology, medicine.disease, medicine.anatomical_structure, ovarian cancer, chemistry, 030220 oncology & carcinogenesis, Original Article, business, Ovarian cancer, serum, Lipoprotein |
| الوصف: | Objective The need for tailoring ovarian cancer treatments to individual patients is increasing. This study aimed to evaluate the prognostic value of pretreatment laboratory test data for predicting the response and survival outcomes of platinum-based chemotherapy in ovarian cancer. Methods We enrolled 270 patients with ovarian cancer diagnosed at the Kyoto Medical Center (n=120; group A) and Kyoto University (n=150; group B). Data on 9 blood parameters (neutrophil to lymphocyte ratio [NLR], platelet to lymphocyte rate [PLR], C-reactive protein, lactate dehydrogenase [LDH], glucose, total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein, and triglyceride levels), cancer pathology, cancer stage, cytoreduction outcomes, serum cancer antigen 125 levels, platinum-free interval (PFI), disease-free survival (DFS), and overall survival were assessed retrospectively. Results NLR, PLR, LDH, and HDL were significantly different in advanced stage patients (P |
| اللغة: | English |
| تدمد: | 2287-8580 2287-8572 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b012cdae66b68c06eafa22f6e1aa80Test http://www.ogscience.org/upload/pdf/ogs-20117.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e3b012cdae66b68c06eafa22f6e1aa80 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22878580 22878572 |
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