Within-lesion heterogeneity of subcortical DWI lesion evolution, and stroke outcome: A voxel-based analysis
| العنوان: | Within-lesion heterogeneity of subcortical DWI lesion evolution, and stroke outcome: A voxel-based analysis |
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| المؤلفون: | Leidy Y Cubillos-Pinilla, Ofer Pasternak, Benno Gesierich, Sophia Stoecklein, Ruth Adam, Marco Duering, Miguel Ángel Araque Caballero, Ebru Baykara, Martin Dichgans, Anna Bayer-Karpinska, Frank A. Wollenweber, Michael Ewers |
| المصدر: | J Cereb Blood Flow Metab Journal of cerebral blood flow & metabolism 40(7), 1482-1491 (2019). doi:10.1177/0271678X19865916 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Stroke patient, Neuroimaging, methods [Image Interpretation, Computer-Assisted], 030204 cardiovascular system & hematology, computer.software_genre, Lesion, 03 medical and health sciences, 0302 clinical medicine, Voxel, Stroke outcome, methods [Diffusion Magnetic Resonance Imaging], Image Interpretation, Computer-Assisted, medicine, diagnostic imaging [Stroke], Humans, ddc:610, cardiovascular diseases, Stroke, Aged, Aged, 80 and over, Subcortical infarction, business.industry, Visible Lesion, Recovery of Function, Original Articles, Middle Aged, medicine.disease, Diffusion Magnetic Resonance Imaging, Neurology, pathology [Stroke], Female, Neurology (clinical), Radiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, methods [Neuroimaging], computer, 030217 neurology & neurosurgery, Diffusion MRI |
| الوصف: | The fate of subcortical diffusion-weighted imaging (DWI) lesions in stroke patients is highly variable, ranging from complete tissue loss to no visible lesion on follow-up. Little is known about within-lesion heterogeneity and its relevance for stroke outcome. Patients with subcortical stroke and recruited through the prospective DEDEMAS study (NCT01334749) were examined at baseline ( n = 45), six months ( n = 45), and three years ( n = 28) post-stroke. We performed high-resolution structural MRI including DWI. Tissue fate was determined voxel-wise using fully automated tissue segmentation. Within-lesion heterogeneity at baseline was assessed by free water diffusion imaging measures. The majority of DWI lesions (66%) showed cavitation on six months follow-up but the proportion of tissue turning into a cavity was small (9 ± 13.5% of the DWI lesion). On average, 69 ± 25% of the initial lesion resolved without any visually apparent signal abnormality. The extent of cavitation at six months post-stroke was independently associated with clinical outcome, i.e. modified Rankin scale score at six months (OR = 4.71, p = 0.005). DWI lesion size and the free water-corrected tissue mean diffusivity at baseline independently predicted cavitation. In conclusion, the proportion of cavitating tissue is typically small, but relevant for clinical outcome. Within-lesion heterogeneity at baseline on advanced diffusion imaging is predictive of tissue fate. |
| تدمد: | 1559-7016 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ab0636f10caa1c7ae2527f7622f7e5Test https://pubmed.ncbi.nlm.nih.gov/31342832Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e3ab0636f10caa1c7ae2527f7622f7e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15597016 |
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