Characteristics of ischemic stroke and intracranial hemorrhage in patients with nephrotic syndrome
| العنوان: | Characteristics of ischemic stroke and intracranial hemorrhage in patients with nephrotic syndrome |
|---|---|
| المؤلفون: | Wen-Yi Huang, Hsiu-Chuan Wu, Kuan-Hsing Chen, Chun-Wei Chang, Chiung-Mei Chen, Kuo-Hsuan Chang, Chien-Hung Chang |
| المصدر: | BMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021) BMC Nephrology |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Subarachnoid hemorrhage, Population, Nephrotic syndrome, Intracranial hemorrhage, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, cardiovascular diseases, education, Stroke, Aged, Proportional Hazards Models, Retrospective Studies, Intracerebral hemorrhage, education.field_of_study, Ischemic stroke, business.industry, Proportional hazards model, Research, Hazard ratio, Retrospective cohort study, Middle Aged, medicine.disease, Diseases of the genitourinary system. Urology, Nephrology, Female, RC870-923, business, Intracranial Hemorrhages, 030217 neurology & neurosurgery |
| الوصف: | Background The incidence of cerebral stroke, including ischemic infarction and intracranial hemorrhage (ICH), increases in patients with nephrotic syndrome (NS). However, the clinical characteristics of patients with NS and stroke remain elusive. We aimed to investigate the clinical presentation and prognosis among patients with NS and ischemic stroke (IS) or ICH. Methods We conducted a population-based retrospective cohort study of patients with NS and acute stroke using the Chang Gung Research Database of Taiwan from January 1, 2001, to December 31, 2017. The participants were recruited from the 7 branches of Chang Gung Memorial Hospital. Results A total of 233 patients with IS and 57 patients with ICH were enrolled. The median age was 60 (52–70) years. The prevalence rates of hyperlipidemia, hyperuricemia, and smoking were higher in IS than in ICH. IS demonstrated lower white blood cell count (7.80 vs. 8.92 × 109/L) and high-sensitivity C-reactive protein level (33.42 vs. 144.10 nmol/L) and higher cholesterol (5.74 vs. 4.84 mmol/L), triglyceride (1.60 vs. 1.28 mmol/L), and albumin (24 vs. 18 g/L) levels compared with ICH. The dependent functional status and 30-day mortality were higher in ICH than in IS. The risk factors for 30-day mortality for patients with NS and stroke were coronary artery disease (CAD), ICH, and total anterior circulation syndrome. The multivariate Cox regression analysis revealed that CAD was positively associated with 30-day mortality in patients with IS (hazard ratio 24.58, 95 % CI 1.48 to 408.90). In patients with ICH, CAD and subarachnoid hemorrhage were positively associated with 30-day mortality (hazard ratio 5.49, 95 % CI 1.54 to 19.56; hazard ratio 6.32, 95 % CI 1.57 to 25.53, respectively). Conclusions ICH demonstrated a higher risk of dependence and 30-day mortality compared with IS in patients with NS. Intensive monitoring and treatment should be applied particularly in patients with NS and ICH. |
| اللغة: | English |
| تدمد: | 1471-2369 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bd02e4e6e3e99749e15028658faeccTest https://doaj.org/article/3207f64032ec44e9ac17dd506c05c6c7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e2bd02e4e6e3e99749e15028658faecc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712369 |
|---|