Life or death? Autophagy in anticancer therapies with statins and histone deacetylase inhibitors
| العنوان: | Life or death? Autophagy in anticancer therapies with statins and histone deacetylase inhibitors |
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| المؤلفون: | Pei Ming Yang, Ching-Chow Chen |
| المصدر: | Autophagy. 7:107-108 |
| بيانات النشر: | Informa UK Limited, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Cyclin-Dependent Kinase Inhibitor p21, Programmed cell death, Cell Survival, Cell, Antineoplastic Agents, Biology, Models, Biological, Neoplasms, Autophagy, medicine, Humans, Molecular Biology, Protein kinase B, Adenylate Kinase, AMPK, Cell Biology, Cell biology, Enzyme Activation, Histone Deacetylase Inhibitors, medicine.anatomical_structure, Cancer cell, Cancer research, Histone deacetylase, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Signal transduction, Proto-Oncogene Proteins c-akt |
| الوصف: | Autophagy, which could be either cytoprotective or cytotoxic, is often observed in tumor cells in response to chemotherapy. Understanding the signaling pathways involved in the regulation of autophagy represents a new direction in the development of anticancer therapies. Our recent studies investigate the role of autophagy in the anticancer effects of statins and histone deacetylase: inhibitors (HDACi). Inhibition of autophagy enhances the efficacy of statins, whereas autophagic cell death in cancer cells is induced by HDACi. Here, we will discuss the differential signaling pathways elicited by statins and HDACi. We find that AMPK, cytoplasmic p21 and Akt signaling are crucial determinants of cell fates (i.e., life or death) while autophagy is induced. |
| تدمد: | 1554-8635 1554-8627 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b54fc08c489548744e66063b7fbf8aTest https://doi.org/10.4161/auto.7.1.13988Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e2b54fc08c489548744e66063b7fbf8a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15548635 15548627 |
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