Incidence of Microvascular Complications in Type 1 Diabetic Subjects with Limited Joint Mobility: A 10-Year Prospective Study
| العنوان: | Incidence of Microvascular Complications in Type 1 Diabetic Subjects with Limited Joint Mobility: A 10-Year Prospective Study |
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| المؤلفون: | G. Crowe, M. J. Quinn, L. Kennedy, M. Smye, David R. McCance |
| المصدر: | Diabetic Medicine. 10:807-810 |
| بيانات النشر: | Wiley, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, Endocrinology, Diabetes and Metabolism, Diabetic angiopathy, Vibration perception, Endocrinology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Prospective Studies, Child, Aged, Glycated Hemoglobin, Type 1 diabetes, Diabetic Retinopathy, business.industry, Incidence, Diabetic retinopathy, Middle Aged, medicine.disease, Surgery, Diabetes Mellitus, Type 1, Female, Microalbuminuria, Joint Diseases, medicine.symptom, business, Diabetic Angiopathies, Follow-Up Studies, Retinopathy |
| الوصف: | Previous cross-sectional studies have shown a significant correlation between limited joint mobility (LJM) and the microvascular complications of Type 1 diabetes, but whether LJM precedes and, therefore, may be regarded as an early marker for complications is unknown. Twenty-two Type 1 diabetic patients (10 male/12 female; diabetes duration at follow-up 20.1 +/- 1.3 (SEM) years) with LJM, and 22 subjects matched for age, sex, and duration of diabetes, without LJM were observed over a 10-year period. Both groups were free of retinopathy and negative for 'dipstick' proteinuria at baseline. After 10 years, of 22 patients with LJM, 10 had developed background and 3 proliferative retinopathy compared with 9 and 1 control subjects, respectively. Microalbuminuria (20or = albumin excretion rate200 micrograms min-1) was present in 3 and macroalbuminuria (albumin excretion rateor = 200 micrograms min-1) in 2 of LJM patients compared with 6 and 1 control subjects, respectively. Ankle and toe vibration perception thresholds, HbA1, mean HbA1 (a mean of serial HbA1 measurements obtained during the 10-year follow-up period), and arterial blood pressure did not differ between the two groups (p0.05). At 10-year review, 9 of the control subjects had developed LJM of whom 4 had retinopathy and 4 microalbuminuria. Thus, while LJM may be another 'chronic complication' of diabetes, its presence does not appear to predict those at increased risk of developing microvascular complications. |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b02755e35b8f11c6840df872d3b357Test https://doi.org/10.1111/j.1464-5491.1993.tb00170.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e2b02755e35b8f11c6840df872d3b357 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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