Acitretin therapy for vulvar lichen sclerosus complicated by recurrent squamous cell carcinoma
| العنوان: | Acitretin therapy for vulvar lichen sclerosus complicated by recurrent squamous cell carcinoma |
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| المؤلفون: | Alison N. Ranum, David R. Pearson |
| المصدر: | JAAD Case Reports, Vol 8, Iss, Pp 53-55 (2021) JAAD Case Reports |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | endocrine system, medicine.medical_specialty, Vulvar Squamous Cell Carcinoma, Acanthosis, Case Report, VAAD, vulvar acanthosis with altered differentiation, Dermatology, LS, Lichen sclerosus, Lichen sclerosus, Acitretin, Vulva, vSCC, vulvar squamous cell carcinoma, 030207 dermatology & venereal diseases, 03 medical and health sciences, lichen sclerosus, 0302 clinical medicine, dVIN, Differentiated vulvar intraepithelial neoplasm, medicine, vLS, vulvar lichen sclerosus, lcsh:Dermatology, Vulvar Lichen Sclerosus, integumentary system, business.industry, vulvar squamous cell carcinoma, vulvar lichen sclerosus, lcsh:RL1-803, medicine.disease, Vulvar intraepithelial neoplasia, female genital diseases and pregnancy complications, Perineum, medicine.anatomical_structure, 030220 oncology & carcinogenesis, business, acitretin, medicine.drug |
| الوصف: | Lichen sclerosus (LS) is a chronic, idiopathic inflammatory disorder with a predilection for the vulva, perineum, and perianal skin. It is characterized by ivory-white scattered to confluent atrophic plaques.1 Women are affected more often than men, and symptoms include, pruritus, burning, and dyspareunia. Symptoms manifested by vulvar LS (vLS) can have significant side effects on sexual functioning, including tearing of the skin, anxiety surrounding sexual activity, and anatomic changes.2 The most serious complication of vLS is the development of vulvar squamous cell carcinoma (vSCC). If untreated, the lifetime incidence of vSCC is estimated at 3.5%-7%.3 Precursor lesions to vSCC include vulvar acanthosis with altered differentiation (VAAD) and vulvar intraepithelial neoplasia. VAAD is an uncommon proliferation of the vulvar squamous epithelium that may have the potential to progress to invasive carcinoma, which may itself be a variant of hypertrophic LS.4,5 Vulvar intraepithelial neoplasia is a high-grade intraepithelial squamous lesion; the human papillomavirus-unrelated differentiated vulvar intraepithelial neoplasm (dVIN) is associated with vLS and more likely to progress to vSCC than the human papillomavirus-related usual type, now more often referred to as high-grade squamous intraepithelial lesion.6 When it progresses, dVIN is usually associated with well-differentiated vSCC. Surgical intervention is typically required for the management of vulvar intraepithelial neoplasia and vSCC but remains controversial for VAAD. Here, we report a case of longstanding vLS complicated by VAAD, dVIN, and recurrent vSCC, which has been successfully managed with acitretin in combination with topical agents. |
| اللغة: | English |
| تدمد: | 2352-5126 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e271c825c71aa8a1874a6bb917eef0a3Test http://www.sciencedirect.com/science/article/pii/S2352512620308559Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e271c825c71aa8a1874a6bb917eef0a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23525126 |
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