Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment
| العنوان: | Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment |
|---|---|
| المؤلفون: | Weitang Yuan, Quanbo Zhou, Bo Shao, Chen Chen, Luyang Zhao, Zhenqiang Sun, Guixian Wang, Yaxin Guo, Xiuxiu Yang, Jinbo Liu |
| المصدر: | Immunology |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | intestinal microbiota, T-Lymphocytes, Immunology, Reviews, Review, Tumor immunity, B7-H1 Antigen, Immune system, Neoplasms, Tumor Microenvironment, Animals, Humans, Immunology and Allergy, Immune Checkpoint Inhibitors, Fusobacterium nucleatum, biology, Macrophages, biology.organism_classification, tumour therapy, Tumor formation, Gastrointestinal Microbiome, Lactobacillus reuteri, Killer Cells, Natural, Disease Models, Animal, stomatognathic diseases, Tumour therapy, Disease Progression, Dysbiosis, immune, Helicobacter hepaticus, tumour microenvironment, Akkermansia muciniphila |
| الوصف: | In recent years, an increasing number of studies have reported that intestinal microbiota have an important effect on tumour immunity by affecting the tumour microenvironment (TME). The intestinal microbiota are closely associated with various immune cells, such as T lymphocytes, natural killer cells (NK cells) and macrophages. Some bacteria, such as Akkermansia muciniphila (A. muciniphila) and Lactobacillus reuteri (L. reuteri), have been shown to improve the effect of tumour immunity. Furthermore, microbial imbalance, such as the increased abundance of Fusobacterium nucleatum (F. nucleatum) and Helicobacter hepaticus (H. hepaticus), generally causes tumour formation and progression. In addition, some microbiota also play important roles in tumour immunotherapy, especially PD‐L1‐related therapies. Therefore, what is the relationship between these processes and how do they affect each other? In this review, we summarize the interactions and corresponding mechanisms among the intestinal microbiota, immune system and TME to facilitate the research and development of new targeted drugs and provide new approaches to tumour therapy. We systematically explored the relationship among intestinal microbiota, immunity and tumour microenvironment. Besides, we also discussed the combined effect of gut microbiota and ICB. In short, the potential of gut microbiota in tumour therapy is promising. |
| تدمد: | 1365-2567 0019-2805 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23e77f581e6c97c20e5d4ca8b7d52beTest https://doi.org/10.1111/imm.13397Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e23e77f581e6c97c20e5d4ca8b7d52be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652567 00192805 |
|---|