Minority children experience a higher risk of death from many central nervous system tumor types even after accounting for treatment received: A National Cancer Database analysis
| العنوان: | Minority children experience a higher risk of death from many central nervous system tumor types even after accounting for treatment received: A National Cancer Database analysis |
|---|---|
| المؤلفون: | Kristin J. Moore, Christopher L. Moertel, Lindsay A. Williams |
| المصدر: | Cancer. 128:1605-1615 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Cancer Research, Adolescent, Infant, Newborn, Infant, Hispanic or Latino, United States, Central Nervous System Neoplasms, Young Adult, Oncology, Child, Preschool, Ethnicity, Humans, Child, Minority Groups, SEER Program |
| الوصف: | Brain tumors are the leading cause of death from disease in children. Racial/ethnic minority children have poorer outcomes than White children; however, it is not clear whether this association is mediated by treatment received.Children (aged 0-19 years) diagnosed with brain tumors in the National Cancer Database (2004-2016) were identified. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) between race/ethnicity (Black, Hispanic, Asian/Pacific Islander, American Indian/Alaska Native, or White [reference]) and death. An inverse odds weighted mediation analysis was performed with treatment received as the mediator.Among 22,469 cases, White children (69% of the sample) had significantly better overall 12.5-year survival (P.01). Black children (13% of the sample) and Hispanic children (14% of the sample) had an increased risk of death overall and for glioblastoma and oligodendroglioma. Compared with Whites, Asian/Pacific Islander children had a higher risk of death from choroid plexus tumors and a lower risk of death from medulloblastoma. There were no statistically significant meditating effects by treatment received, although the estimate was borderline in Hispanic children (indirect HR, 1.08; 95% CI, 0.99-1.18). A treatment-independent association between race/ethnicity and death remained for Hispanic children (direct HR, 1.18; 95% CI, 1.04-1.33) and Black children (direct HR, 1.28; 95% CI, 1.13-1.45). If deaths in minorities had equaled those in White children, 5% fewer total deaths and 15% fewer minority deaths would have occurred.Survival disparities exist in pediatric brain tumors and are largely independent of treatment received, but other mechanisms linked to race/ethnicity remain important. |
| تدمد: | 1097-0142 0008-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23bb3baf74e99c1f9640a7254a47169Test https://doi.org/10.1002/cncr.34121Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e23bb3baf74e99c1f9640a7254a47169 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
|---|