Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism
| العنوان: | Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism |
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| المؤلفون: | Jimmy D. Bell, J. Gibney, Nicola Jackson, Anne Umpleby, S. B. Bowes, Richard H. Jones, M Stolinski, Kevin C.R. Baynes, Fariba Shojaee-Moradie, E. L. Thomas, Martin Whyte, D. Lovell, Claire Pentecost |
| المصدر: | Diabetologia. 50:404-413 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Glucose uptake, medicine.medical_treatment, Palmitic Acid, Physical exercise, Fatty Acids, Nonesterified, Biology, Carbohydrate metabolism, Body Mass Index, NEFA, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Insulin, Lipolysis, Exercise, Life Style, Fatty Acids, Middle Aged, Overweight, Glucose clamp technique, medicine.disease, Endocrinology, Glucose Clamp Technique |
| الوصف: | AIMS/HYPOTHESIS: It is not known whether the beneficial effects of exercise training on insulin sensitivity are due to changes in hepatic and peripheral insulin sensitivity or whether the changes in insulin sensitivity can be explained by adaptive changes in fatty acid metabolism, changes in visceral fat or changes in liver and muscle triacylglycerol content. We investigated the effects of 6 weeks of supervised exercise in sedentary men on these variables. SUBJECTS AND METHODS: We randomised 17 sedentary overweight male subjects (age 50 +/- 2.6 years, BMI 27.6 +/- 0.5 kg/m(2)) to a 6-week exercise programme (n = 10) or control group (n = 7). The insulin sensitivity of palmitic acid production rate (Ra), glycerol Ra, endogenous glucose Ra (EGP), glucose uptake and glucose metabolic clearance rate were measured at 0 and 6 weeks with a two-step hyperinsulinaemic-euglycaemic clamp [step 1, 0.3 (low dose); step 2, 1.5 (high dose) mU kg(-1) min(-1)]. In the exercise group subjects were studied >72 h after the last training session. Liver and skeletal muscle triacylglycerol content was measured by magnetic resonance spectroscopy and visceral adipose tissue by cross-sectional computer tomography scanning. RESULTS: After 6 weeks, fasting glycerol, palmitic acid Ra (p = 0.003, p = 0.042) and NEFA concentration (p = 0.005) were decreased in the exercise group with no change in the control group. The effects of low-dose insulin on EGP and of high-dose insulin on glucose uptake and metabolic clearance rate were enhanced in the exercise group but not in the control group (p = 0.026; p = 0.007 and p = 0.04). There was no change in muscle triacylglycerol and liver fat in either group. CONCLUSIONS/INTERPRETATION: Decreased availability of circulating NEFA may contribute to the observed improvement in the insulin sensitivity of EGP and glucose uptake following 6 weeks of moderate exercise. |
| تدمد: | 1432-0428 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fd8bc0ceb2a77c3ccadbef11b67a83Test https://doi.org/10.1007/s00125-006-0498-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e1fd8bc0ceb2a77c3ccadbef11b67a83 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
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