Dietary Intake of Eicosapentaenoic and Docosahexaenoic Acid and Diabetic Nephropathy: Cohort Analysis of the Diabetes Control and Complications Trial
| العنوان: | Dietary Intake of Eicosapentaenoic and Docosahexaenoic Acid and Diabetic Nephropathy: Cohort Analysis of the Diabetes Control and Complications Trial |
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| المؤلفون: | Deborah J. Wexler, Chee-Tin Christine Lee, Stephen J. Sharp, Amanda I Adler |
| المصدر: | Diabetes Care |
| بيانات النشر: | American Diabetes Association, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Docosahexaenoic Acids, Endocrinology, Diabetes and Metabolism, Severity of Illness Index, Gastroenterology, Cohort Studies, Diabetic nephropathy, Young Adult, Risk Factors, Internal medicine, Diabetes mellitus, Fatty Acids, Omega-3, Internal Medicine, Albuminuria, Humans, Medicine, Diabetic Nephropathies, Longitudinal Studies, Prospective cohort study, Original Research, Randomized Controlled Trials as Topic, Advanced and Specialized Nursing, chemistry.chemical_classification, Type 1 diabetes, business.industry, Incidence, Clinical Care/Education/Nutrition/Psychosocial Research, Feeding Behavior, medicine.disease, Eicosapentaenoic acid, Diabetes Mellitus, Type 1, Endocrinology, Eicosapentaenoic Acid, chemistry, Docosahexaenoic acid, Female, medicine.symptom, business, Follow-Up Studies, Polyunsaturated fatty acid |
| الوصف: | OBJECTIVE To investigate the association between dietary n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) and the degree and development of albuminuria in type 1 diabetes. RESEARCH DESIGN AND METHODS We analyzed longitudinal data from 1,436 participants in the Diabetes Control and Complications Trial. We defined the average intake of eicosapentaenoic and docosahexaenoic acid from diet histories. Urinary albumin excretion rates (UAERs) were measured over 24 h; incident albuminuria was considered the first occurrence of an UAER >40 mg/24 h sustained for ≥1 year in normoalbuminuric individuals. RESULTS In a mean follow-up of 6.5 years, we observed a lower mean UAER (difference 22.7 mg/24 h [95% CI 1.6–43.8)]) in the top versus the bottom third of dietary n-3 LC-PUFAs, but we found no association with incident albuminuria. CONCLUSIONS Dietary n-3 LC-PUFAs appear inversely associated with the degree but not with the incidence of albuminuria in type 1 diabetes. These findings require further investigation in prospective studies. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e198f1c38a891912047fc5bcb039e870Test https://doi.org/10.2337/dc09-2245Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e198f1c38a891912047fc5bcb039e870 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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