Effect of diltiazem on 2,4-D-induced myotonia in rats
| العنوان: | Effect of diltiazem on 2,4-D-induced myotonia in rats |
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| المؤلفون: | William H. Olson, Vasudeva G. Iyer, Saad Al-Rajeh |
| المصدر: | Muscle & Nerve. 12:470-472 |
| بيانات النشر: | Wiley, 1989. |
| سنة النشر: | 1989 |
| مصطلحات موضوعية: | medicine.medical_specialty, Contraction (grammar), Physiology, In Vitro Techniques, Myotonia, Diltiazem, Cellular and Molecular Neuroscience, Calcium Channel Blocking Drugs, Physiology (medical), Internal medicine, medicine, Animals, Direct stimulation, business.industry, Skeletal muscle, Rats, Inbred Strains, medicine.disease, Rats, Endocrinology, medicine.anatomical_structure, Rat Diaphragm, Neurology (clinical), 2,4-Dichlorophenoxyacetic Acid, Calcium channel blocking agent, business, Muscle Contraction, medicine.drug |
| الوصف: | Myotonia is characterized by prolonged contraction (delay in onset of relaxation) of skeletal muscle fibers with characteristic electromyographic findings. Calcium channel blocking drugs may be expected to reduce myotonia, should they promote the onset of relaxation in a contracted skeletal muscle. This study was aimed at evaluating the effect of diltiazem, a calcium channel blocking agent, on myotonia induced by 2,4-dichlorophenoxyacetic acid (2,4-D). In rat diaphragm, exposed to 2.5 mM 2,4-D in a tissue bath, myotonia was quantified by documenting the contraction time in response to direct stimulation with supramaximal electric stimuli. At the peak of myotonia, different concentrations of diltiazem were added to the tissue bath and the effect on evoked contraction studied over a period of 6 minutes. A concentration of 5 × 10−5M was found to be the most effective, causing a decrease in contraction time of more than 90% in 3 minutes in 100% of specimens (n = 7). The above findings raise the possibility of using diltiazem as an antimyotonic agent. |
| تدمد: | 1097-4598 0148-639X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d57e8298f57c212caa2324cc6bc4ebTest https://doi.org/10.1002/mus.880120606Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e0d57e8298f57c212caa2324cc6bc4eb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974598 0148639X |
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