Effect of metformin on clinical and biochemical hyperandrogenism in adolescent girls with type 1 diabetes
| العنوان: | Effect of metformin on clinical and biochemical hyperandrogenism in adolescent girls with type 1 diabetes |
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| المؤلفون: | Menna Elbarbary, Noha Musa, Mona Hafez, Sahar Abdel Atty, Maha M. Amin, Shaimaa Elbehairy |
| المصدر: | Journal of Pediatric Endocrinology and Metabolism. 32:461-470 |
| بيانات النشر: | Walter de Gruyter GmbH, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, 030209 endocrinology & metabolism, Luteal phase, Young Adult, 03 medical and health sciences, Follicle-stimulating hormone, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, medicine, Humans, Hypoglycemic Agents, Prospective Studies, Child, Ovulation, hirsutism, media_common, 030219 obstetrics & reproductive medicine, business.industry, Hyperandrogenism, Prognosis, medicine.disease, Metformin, Diabetes Mellitus, Type 1, Pediatrics, Perinatology and Child Health, Female, Luteinizing hormone, business, Biomarkers, Follow-Up Studies, medicine.drug |
| الوصف: | Background Hyperandrogenism with or without polycystic ovarian syndrome is seen in adolescents with type 1 diabetes (T1D), especially those with suboptimal control. Objective To assess the effect of metformin on hyperandrogenism and ovarian function in adolescents with T1D. Methods This prospective study included 28 T1D females showing signs of hyperandrogenism. History taking (detailed diabetes history and menstrual history) and anthropometric measurements (weight, height, body mass index [BMI], waist and hip circumference) were initially performed, and then the patients were assessed for the manifestations of hyperandrogenism (acne, hirsutism as well as pelvic ultrasound [U/S] for ovarian morphology). Biochemical evaluation for ovulation (progesterone assessment during the luteal phase), sex steroids (estradiol, testosterone, dehydroepiandrosterone sulfate [DHEAS] and androstenedione), prolactin, glycemic control (hemoglobin A1c [HbA1c]) and gonadotropin levels (follicle stimulating hormone [FSH] and luteinizing hormone [LH]) was done. Patients were subjected to 500 mg metformin twice daily orally for 1 year, and then the patients were re-evaluated for clinical and biochemical parameters. Results Metformin therapy resulted in a significant reduction in weight (p = 0.001), BMI (p = 0.002), acne (p = 0.008), hirsutism score (0.007), LH (p = 0.008), testosterone (p 1c (p = 0.068). Nausea and/or abdominal pain were the commonly reported side effects of metformin (64%). Conclusions Metformin as an insulin sensitizing agent improved the BMI and cycle regularity together with clinical and biochemical hyperandrogenism in T1D adolescent girls. However, it did not improve their glycemic control. |
| تدمد: | 2191-0251 0334-018X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b743b4d498b12df0d1bb370cbd77b1Test https://doi.org/10.1515/jpem-2018-0430Test |
| رقم الانضمام: | edsair.doi.dedup.....e0b743b4d498b12df0d1bb370cbd77b1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21910251 0334018X |
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