Impact of extracellular‐to‐intracellular fluid volume ratio on albuminuria in patients with type 2 diabetes: A cross‐sectional and longitudinal cohort study
| العنوان: | Impact of extracellular‐to‐intracellular fluid volume ratio on albuminuria in patients with type 2 diabetes: A cross‐sectional and longitudinal cohort study |
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| المؤلفون: | Hiroshi Okada, Michiaki Fukui, Ayumi Kaji, Emi Ushigome, Masahiro Yamazaki, Saori Majima, Masahide Hamaguchi, Yuta Yoshimura, Takufumi Senmaru, Fuyuko Takahashi, Ryosuke Sakai, Takuro Okamura, Yoshitaka Hashimoto, Ryo Bamba, Noriyuki Kitagawa, Naoko Nakanishi, Hanako Nakajima, Mai Asano |
| المصدر: | Journal of Diabetes Investigation, Vol 12, Iss 7, Pp 1202-1211 (2021) Journal of Diabetes Investigation |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Intracellular Fluid, Male, Endocrinology, Diabetes and Metabolism, Water-Electrolyte Imbalance, 030232 urology & nephrology, Type 2 diabetes, 030204 cardiovascular system & hematology, 0302 clinical medicine, Reference Values, Extracellular fluid, Electric Impedance, Medicine, Longitudinal Studies, Articles, General Medicine, Middle Aged, Water-Electrolyte Balance, Clinical Science and Care, Creatinine, Fluid overload, Regression Analysis, Female, Original Article, medicine.symptom, Bioelectrical impedance analysis, Cohort study, medicine.medical_specialty, Urinary system, Urology, Risk Assessment, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Body fluid volume, Albumins, Diabetes mellitus, Internal Medicine, Albuminuria, Humans, Diabetic kidney disease, Aged, business.industry, Extracellular Fluid, medicine.disease, RC648-665, Confidence interval, Cross-Sectional Studies, Diabetes Mellitus, Type 2, ROC Curve, business |
| الوصف: | Aims/Introduction Body fluid volume imbalance is common in patients with kidney failure, and is associated with all‐cause mortality. This study aimed to investigate the association between fluid volume imbalance and albuminuria in patients with type 2 diabetes mellitus without kidney failure. Materials and Methods Using data from one cohort study, a baseline cross‐sectional study of 432 participants and a longitudinal cohort study of 368 participants who could follow up was carried out. Body fluid imbalance was determined by measuring the extracellular water (ECW)‐to‐intracellular water (ICW) ratio (ECW/ICW) using bioelectrical impedance analysis. A change in the urinary albumin‐to‐creatinine ratio (ACR) was defined as the ratio of urinary ACR at follow up to that at baseline. The ECW/ICW ratio was compared with the level of albuminuria. Results In this cross‐sectional study, the ECW/ICW ratio increased with the level of albuminuria. There was an association between the ECW/ICW ratio and logarithms of urinary ACR after adjusting for covariates (β = 0.205, P 300 mg/gCr, was 0.648 (area under the curve 0.78, 95% confidence interval 0.58–0.90). Conclusions The ECW/ICW ratio is independently associated with the level of albuminuria in patients with type 2 diabetes mellitus without kidney failure. This reinforces the importance of monitoring fluid balance in patients with type 2 diabetes mellitus. Fluid imbalance occurred in diabetes patients without kidney failure, and was associated with the level of albuminuria. The extracellular water to intracellular water ratio is independently associated with changes in albuminuria in patients with type 2 diabetes mellitus without kidney failure. Clinicians need to pay more attention to monitoring the fluid status among patients with type 2 diabetes mellitus, and maintaining fluid balance in the early stage of diabetic kidney disease. |
| اللغة: | English |
| تدمد: | 2040-1116 2040-1124 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04eec44f6ad3d6c331237c388316192Test https://doaj.org/article/46b7ba851b5d42ef93ad4f383baecffbTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e04eec44f6ad3d6c331237c388316192 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20401116 20401124 |
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