Normal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid
| العنوان: | Normal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid |
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| المؤلفون: | Abhaya V. Kulkarni, Benjamin C. Warf, Steven J. Schiff, Joseph N. Paulson, Venkateswararao Cherukuri, Paddy Ssentongo, Vishal Monga, Mallory R. Peterson |
| المصدر: | Journal of neurosurgery. Pediatrics |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Adolescent, Population, Physiology, brain volume, Body size, growth curves, Article, cerebrospinal fluid, Functional Laterality, Cohort Studies, Cerebrospinal fluid, Child Development, medicine, Humans, Fluid accumulation, Child, Analysis of Variance, Sex Characteristics, medicine.diagnostic_test, Anthropometry, business.industry, Body Weight, Infant, Newborn, Brain, Infant, Magnetic resonance imaging, General Medicine, Organ Size, Reference Standards, medicine.disease, Magnetic Resonance Imaging, Hydrocephalus, Brain growth, Child, Preschool, Brain size, Female, Analysis of variance, business, hydrocephalus, Algorithms |
| الوصف: | OBJECTIVE The study of brain size and growth has a long and contentious history, yet normal brain volume development has yet to be fully described. In particular, the normal brain growth and cerebrospinal fluid (CSF) accumulation relationship is critical to characterize because it is impacted in numerous conditions of early childhood in which brain growth and fluid accumulation are affected, such as infection, hemorrhage, hydrocephalus, and a broad range of congenital disorders. The authors of this study aim to describe normal brain volume growth, particularly in the setting of CSF accumulation. METHODS The authors analyzed 1067 magnetic resonance imaging scans from 505 healthy pediatric subjects from birth to age 18 years to quantify component and regional brain volumes. The volume trajectories were compared between the sexes and hemispheres using smoothing spline ANOVA. Population growth curves were developed using generalized additive models for location, scale, and shape. RESULTS Brain volume peaked at 10–12 years of age. Males exhibited larger age-adjusted total brain volumes than females, and body size normalization procedures did not eliminate this difference. The ratio of brain to CSF volume, however, revealed a universal age-dependent relationship independent of sex or body size. CONCLUSIONS These findings enable the application of normative growth curves in managing a broad range of childhood diseases in which cognitive development, brain growth, and fluid accumulation are interrelated. |
| اللغة: | English |
| تدمد: | 1933-0715 1933-0707 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfece028833e8d636587ba6d80dacf93Test http://europepmc.org/articles/PMC8594737Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dfece028833e8d636587ba6d80dacf93 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19330715 19330707 |
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