Abnormalities of quantities and functions of natural killer cells in severe aplastic anemia
| العنوان: | Abnormalities of quantities and functions of natural killer cells in severe aplastic anemia |
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| المؤلفون: | Rong Fu, Lijuan Li, Weiwei Sheng, Limin Xing, Tian Zhang, Huaquan Wang, Yuhong Wu, Zhishang Li, Zonghong Shao, Jia Song, Chunyan Liu |
| المصدر: | Immunological Investigations. 43:491-503 |
| بيانات النشر: | Informa UK Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Adolescent, animal diseases, Immunology, Granzymes, Immunophenotyping, Leukocyte Count, Young Adult, Interleukin 21, Immune system, hemic and lymphatic diseases, medicine, Humans, RNA, Messenger, Aplastic anemia, Child, Aged, Chromosome Aberrations, Innate immune system, biology, Natural Cytotoxicity Triggering Receptor 1, Perforin, Platelet Count, Bone marrow failure, Anemia, Aplastic, General Medicine, Middle Aged, NKG2D, medicine.disease, Killer Cells, Natural, Haematopoiesis, Phenotype, Treatment Outcome, NK Cell Lectin-Like Receptor Subfamily K, Case-Control Studies, Child, Preschool, biology.protein, Female, Immunosuppressive Agents |
| الوصف: | Severe aplastic anemia (SAA) is a rare disease characterized by severe pancytopenia and bone marrow failure. Natural killer (NK) cells are large granular lymphocytes derived from hematopoietic stem cells (HSCs) or common lymphoid progenitors (CLP). They play a key role in n the innate immunity and adaptive immune. In this study, the quantitative and functional changes of natural killer (NK) cell subsets in peripheral blood of severe aplastic anemia (SAA) patients before and after immunosuppressive therapy (IST) were investigated. Results showed that the percentage of NK cells and its subsets in peripheral blood lymphocytes was decreased in SAA patients. After IST, the percentage of NK cells and their subsets increased dramatically. The median expressions of CD158a, NKG2D and NKp46 on NK cells were higher in SAA patients compared to that in normal controls, and the expressions of perforin in newly diagnosed and recovery SAA patients were higher than that in controls. Therefore, we concluded that the decrease of total NK cells, and CD56(bright), CD56(dim) NK cell subsets and the higher expressions of NKp46 and perforin on NK cells may cause the over-function of T lymphocytes and thus lead to hematopoiesis failure in SAA. |
| تدمد: | 1532-4311 0882-0139 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df73ee15ee518036b9ddb0768c271206Test https://doi.org/10.3109/08820139.2014.888448Test |
| رقم الانضمام: | edsair.doi.dedup.....df73ee15ee518036b9ddb0768c271206 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15324311 08820139 |
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