HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules
| العنوان: | HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules |
|---|---|
| المؤلفون: | Silke Kummer, William W. Kwok, Thomas Jacobs, Julian Schulze zur Wiesch, Ansgar W. Lohse, Sven Peine, Matthias Marget, Tobias Boettler, Christin Ackermann, Thomas Kuntzen, Robin Woost, Maike Smits, Johanna M. Eberhard |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, CD226, Programmed Cell Death 1 Receptor, BTLA, lcsh:Medicine, Hepacivirus, Immunological memory, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, TIGIT, MHC class I, Humans, Medicine, Receptors, Immunologic, Receptor, lcsh:Science, Hepatitis A Virus Cellular Receptor 2, Aged, Multidisciplinary, biology, Hepatitis C virus, business.industry, T-cell receptor, lcsh:R, Histocompatibility Antigens Class II, virus diseases, Hepatitis C, Chronic, Middle Aged, Receptors, OX40, Hepatitis C, digestive system diseases, Chronic infection, 030104 developmental biology, Acute Disease, Immunology, biology.protein, Female, lcsh:Q, business, 030217 neurology & neurosurgery, CD8 |
| الوصف: | The combined regulation of a network of inhibitory and activating T cell receptors may be a critical step in the development of chronic HCV infection. Ex vivo HCV MHC class I + II tetramer staining and bead-enrichment was performed with baseline and longitudinal PBMC samples of a cohort of patients with acute, chronic and spontaneously resolved HCV infection to assess the expression pattern of the co-inhibitory molecule TIGIT together with PD-1, BTLA, Tim-3, as well as OX40 and CD226 (DNAM-1) of HCV-specific CD4+ T cells, and in a subset of patients of HCV-specific CD8+ T cells. As the main result, we found a higher expression level of TIGIT+ PD-1+ on HCV-specific CD4+ T cells during acute and chronic HCV infection compared to patients with spontaneously resolved HCV infection (p |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df54b52b1f824ed57f6415d962a118eaTest http://link.springer.com/article/10.1038/s41598-019-47024-8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....df54b52b1f824ed57f6415d962a118ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
|---|