PD‐L1 expression, CD8+ and CD4+ lymphocyte rate are predictive of pathological complete response after neoadjuvant chemoradiotherapy for squamous cell cancer of the thoracic esophagus
| العنوان: | PD‐L1 expression, CD8+ and CD4+ lymphocyte rate are predictive of pathological complete response after neoadjuvant chemoradiotherapy for squamous cell cancer of the thoracic esophagus |
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| المؤلفون: | Massimo Rugge, Andromachi Kotsafti, Rita Alfieri, Luca Maria Saadeh, Melania Scarpa, Matteo Fassan, Francesco Cavallin, Marco Scarpa, Carlo Castoro, Ignazio Castagliuolo, Vincenza Guzzardo, Matteo Cagol, Vanna Chiarion-Sileni |
| المصدر: | Cancer Medicine, Vol 8, Iss 13, Pp 6036-6048 (2019) Cancer Medicine |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Male, squamous cell carcinoma, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Esophageal Neoplasms, medicine.medical_treatment, Lymphocyte, Kaplan-Meier Estimate, CD8-Positive T-Lymphocytes, lcsh:RC254-282, Gastroenterology, B7-H1 Antigen, survival analysis, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Lymphocyte Count, esophageal cancer, neoadjuvant therapy, Esophagus, Neoadjuvant therapy, Survival analysis, Aged, Original Research, Cancer Biology, induction chemoradiotherapy, business.industry, FOXP3, Retrospective cohort study, Middle Aged, Esophageal cancer, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Female, Esophageal Squamous Cell Carcinoma, Neoplasm Recurrence, Local, business, CD8 |
| الوصف: | Background Neoadjuvant chemoradiotherapy (CTRT) can effectively downstage esophageal squamous cell carcinoma (SCC) in patients with locally advanced disease and prolonged survival have been observed in patients with a pathological complete response (ypCR). Aims and methods This exploratory study aimed to identify immunological predictors of pCR after neoadjuvant CTRT within SCC microenvironment. The tumor regression after neoadjuvant therapy was measured according to the Mandard score system. Eighty‐eight consecutive patients with SCC of the thoracic esophagus who received neoadjuvant CTRT were included in this retrospective study. Inclusion criteria were neoadjuvant CTRT and the availability of representative histological samples taken at diagnosis. We investigated immunohistochemical expression of CD4, Tbet, FoxP3, CD8, CD80, PD‐L1, and PD‐1, in the pretreatment biopsies and correlated the immunohistochemical profiles to patients’ outcomes. Results After neoadjuvant CTRT, 23 patients had pCR, while 65 ones had partial response, stable disease or progression. PD‐L1 expression and CD8+ and CD4+ lymphocyte rate were significantly higher in patients who had ypCR compared to those who had not (10 (0‐55) vs 0 (0‐0), P = 0.004, 73 (36‐147) vs 21 (7‐47), P = 0.0006 and 39 (23‐74) vs 5 (0‐13), P Mucosal expression of PDL1 and CD8+ and CD4+ lymphocyte rate is predictive of clinical complete response after neoadjuvant CT‐RT for SCC of the thoracic esophagus with adequate accuracy. Furthermore, recurrence/relapse after complete response is associated with high level of CD4+ T cell infiltration. |
| تدمد: | 2045-7634 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df244954adfcc5e10b60d4e57de9dd0dTest https://doi.org/10.1002/cam4.2359Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....df244954adfcc5e10b60d4e57de9dd0d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20457634 |
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