Epitope-Restricted 65-Kilodalton Glutamic Acid Decarboxylase Autoantibodies among New-Onset Sardinian Type 2 Diabetes Patients Define Phenotypes of Autoimmune Diabetes
| العنوان: | Epitope-Restricted 65-Kilodalton Glutamic Acid Decarboxylase Autoantibodies among New-Onset Sardinian Type 2 Diabetes Patients Define Phenotypes of Autoimmune Diabetes |
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| المؤلفون: | Christiane S. Hampe, Lisa K. Gilliam, Loreta Puddu, Domenica Anna Obinu, Mario Maioli, Åke Lernmark, Lynn M. Bekris, Giancarlo Tonolo, Kristian Lynch, Alberto Manconi, Emilyn U. Alejandro |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 89:5675-5682 |
| بيانات النشر: | The Endocrine Society, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Glutamate decarboxylase, Type 2 diabetes, medicine.disease_cause, Biochemistry, Epitope, Body Mass Index, Autoimmunity, Epitopes, Endocrinology, Internal medicine, Humans, Medicine, Aged, Autoantibodies, Type 1 diabetes, C-Peptide, biology, Glutamate Decarboxylase, business.industry, Biochemistry (medical), Autoantibody, nutritional and metabolic diseases, Type 2 Diabetes Mellitus, Middle Aged, medicine.disease, Isoenzymes, Diabetes Mellitus, Type 1, Phenotype, Diabetes Mellitus, Type 2, biology.protein, Female, Antibody, business |
| الوصف: | The 65-kDa glutamic acid decarboxylase (GAD65) autoantibodies (GAD65Abs), commonly found in type 1 diabetes mellitus (T1DM) patients, are also found at lower frequencies in type 2 diabetes mellitus (T2DM) patients. GAD65Abs in T1DM patients are epitope specific, in contrast to those found in other GAD65Ab-positive individuals, including T2DM patients. Our aim was to assess whether epitope-specific GAD65Abs, or the additional presence of islet antigen 2 (IA-2) autoantibodies, better define T1DM phenotypes among T2DM patients. GAD65 and IA-2 autoantibodies were analyzed in 1436 Sardinian subjects classified with T2DM and in 384 nondiabetic patient controls. Autoantibody binding specificity to the N-terminal, middle (M), and C-terminal (C) portions of the GAD65 molecule was evaluated. Among the T2DM patients, 5.1% had GAD65 (P < 0.001) and 2.4% had IA-2 autoantibodies, compared with 1.3 and 1.6%, respectively, among the controls. GAD65Ab-positive T2DM patients with M+C (epitope-specific) reactivity were found to have the lowest body mass index (P < 0.001), followed by GAD65Ab/IA-2Ab-positive patients (P < 0.01), and non-M+C-reactive (non-epitope-specific) patients (P < 0.02). In GAD65Ab-positive T2DM patients, c-peptide levels were lower in M+C-reactive compared with non-M+C-reactive patients. Sardinian T2DM patients with M+C-predominant GAD65Ab reactivity have clinical features more similar to those of T1DM patients. Thus, GAD65Ab epitope analysis may help to define T1DM phenotypes among newly diagnosed GAD65Ab-positive patients classified with T2DM. |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1dfe963cbccf260fab10e1b6fcfdd8Test https://doi.org/10.1210/jc.2004-0864Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....df1dfe963cbccf260fab10e1b6fcfdd8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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