Concentration of Zinc, Copper, Iron, Calcium, and Magnesium in the Serum, Tissues, and Urine of Streptozotocin-Induced Mild Diabetic Rat Model
| العنوان: | Concentration of Zinc, Copper, Iron, Calcium, and Magnesium in the Serum, Tissues, and Urine of Streptozotocin-Induced Mild Diabetic Rat Model |
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| المؤلفون: | José L. Molina, Sonia Clapés, Angel Mollineda, Leticia Bequer, Alain Álvarez, Mayrelis Lavastida, Tahiry Gómez |
| المصدر: | Biological Trace Element Research. 179:237-246 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, endocrine system diseases, Iron, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, chemistry.chemical_element, 030209 endocrinology & metabolism, Zinc, Urine, Calcium, Biochemistry, Streptozocin, Diabetes Mellitus, Experimental, Inorganic Chemistry, Excretion, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, medicine, Animals, Magnesium, Micronutrients, Rats, Wistar, Kidney, Biochemistry (medical), Reproducibility of Results, nutritional and metabolic diseases, General Medicine, medicine.disease, Streptozotocin, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Female, Copper, medicine.drug |
| الوصف: | The present study aimed to investigate, in the streptozotocin-induced mild diabetic rat model, the zinc (Zn), copper (Cu), iron (Fe), calcium (Ca), and magnesium (Mg) concentration in serum, liver, and kidney tissues, and urine samples from adult Wistar rats treated neonatally with streptozotocin (STZ). Diabetes was induced by subcutaneous administration of streptozotocin (100 mg/Kg) in female Wistar rats of 2 days old (STZ, n = 10). Control group (CG, n = 10) received only sodium-citrate buffer. The mineral concentrations were measured by atomic absorption spectrophotometry. The validity and accuracy were checked by conventional methods. STZ neonatal injection successfully leaded to mild diabetes in the adult rats. Serum concentrations of Zn, Cu, Fe, Ca, and Mg showed no changes (p 0.05) due to diabetes. The Zn, Fe, Ca, and Mg concentrations in liver and kidney tissues were not different (p 0.05) between STZ and CG. The mean values of Cu were higher (p 0.05) in liver and kidney samples from STZ as compared to CG. Urine minerals concentrations (Zn, Cu, Fe and Ca) in STZ-rats group were lower (p 0.05) than CG. However, the content of all evaluated minerals in the excreted urine were higher (p 0.01) in STZ-rats during a 24 h collection period. Urinary excretion of Zn, Cu, Fe, Ca, and Mg was strongly correlated with urinary volume during the 24 h period (r 0.7; p 0.001). Observed changes in mineral metabolism of STZ-induced mild diabetes model could be due to the endocrine imbalance associated with the diabetic condition. |
| تدمد: | 1559-0720 0163-4984 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0d60b9fcfb878daec36ff66506bab7Test https://doi.org/10.1007/s12011-017-0962-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....de0d60b9fcfb878daec36ff66506bab7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590720 01634984 |
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