Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration
| العنوان: | Baseline predictors for subretinal fibrosis in neovascular age-related macular degeneration |
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| المؤلفون: | Philipp K. Roberts, Markus Schranz, Alice Motschi, Sylvia Desissaire, Valentin Hacker, Michael Pircher, Stefan Sacu, Wolf Buehl, Christoph K. Hitzenberger, Ursula M. Schmidt-Erfurth |
| المصدر: | Scientific Reports Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022) |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Time Factors, genetic structures, Science, Visual Acuity, Angiogenesis Inhibitors, Retinal Neovascularization, Retina, Article, Macular Degeneration, Prognostic markers, Predictive Value of Tests, Photography, Humans, Longitudinal Studies, Prospective Studies, Fluorescein Angiography, Signs and symptoms, Aged, Aged, 80 and over, Multidisciplinary, Diagnostic markers, Middle Aged, Fibrosis, eye diseases, Treatment Outcome, Medicine, Female, sense organs, Tomography, Optical Coherence, Biomarkers |
| الوصف: | To find baseline predictors for subretinal fibrosis (SF) in neovascular age-related macular degeneration (nAMD). Forty-five eyes of 45 participants with treatment-naïve nAMD were consecutively enrolled and treated according to a standardized treat-and-extend protocol. Spectral-domain optical coherence tomography (OCT), color fundus photography and fluorescein angiography as well as novel imaging modalities polarization-sensitive OCT and OCT angiography (OCTA) were performed to detect SF after 1 year and find baseline predictors for SF development. Baseline OCTA scans were evaluated for quantitative features such as lesion area, vessel area, vessel junctions, vessel length, vessel endpoints and mean lacunarity. Additionally, the type of macular neovascularization, the presence of subretinal fluid, intraretinal fluid (IRF), subretinal hyperreflective material (SHRM), retinal hemorrhage as well as best-corrected visual acuity (BCVA) were evaluated. After 12 months 8 eyes (18%) developed SF. Eyes with SF had worse baseline BCVA (p = .001) and a higher prevalence of IRF (p = .014) and SHRM at baseline (p = .017). There was no significant difference in any of the evaluated quantitative OCTA parameters (p > .05) between eyes with and without SF. There were no quantitative baseline microvascular predictors for SF in our study. Low baseline BCVA, the presence of IRF and SHRM, however, are easily identifiable baseline parameters indicating increased risk. |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf741131942d7a5c779b730ae9c18baTest https://doi.org/10.1038/s41598-021-03716-8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ddf741131942d7a5c779b730ae9c18ba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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